Clone:
REA287
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
MAC-inhibitory protein (MAC-IP), Membrane attack complex inhibition factor (MACIF), Protectin, CD59

Specifications for CD59a Antibody, anti-mouse, REAfinity™

Overview

Clone REA287 recognizes the CD59a antigen, the murine analog of human CD59 which is also known as MAC-inhibitory protein (MAC-IP) or membrane attack complex inhibition factor (MACIF). CD59a is widely distributed, being present on all circulating cells, epithelia, and endothelia and in most tissues examined. CD59a blocks the formation of the membrane attack complex of complement by inhibiting binding of C9 to the C5b-8 complex, hereby protecting the cells from complement-mediated lysis. Further, CD59a down-modulates CD4
+
T cell activity
in vitro
and
in vivo
, thereby revealing another link between complement regulators and T cell activation.
Additional information: Clone REA287 displays negligible binding to Fc receptors.

Alternative names

MAC-inhibitory protein (MAC-IP), Membrane attack complex inhibition factor (MACIF), Protectin, CD59

Detailed product information

Technical specifications

CloneREA287
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenCD59a
Alternative names of antigenMAC-inhibitory protein (MAC-IP), Membrane attack complex inhibition factor (MACIF), Protectin, CD59
Molecular mass of antigen [kDa]8
Distribution of antigenendothelial cells, epithelial cells, leukocytes
Entrez Gene ID12509
RRIDAB_2658787, AB_2658788, AB_2658789, AB_2658790, AB_2658791, AB_2658792, AB_2658793, AB_2658786

Resources for CD59a Antibody, anti-mouse, REAfinity™

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for CD59a Antibody, anti-mouse, REAfinity™

Publications

  1. Longhi, M. P. et al. (2005) Cutting edge: murine CD59a modulates antiviral CD4+ T cell activity in a complement-independent manner. J. Immunol. 175(11): 7098-7102
  2. Powell, M. B. et al. (1997) Molecular cloning, chromosomal localization, expression, and functional characterization of the mouse analogue of human CD59. J. Immunol. 158(4): 1692-1702
  3. Harhausen, D. et al. (2010) Membrane attack complex inhibitor CD59a protects against focal cerebral ischemia in mice. J. Neuroinflammation 4(7): 15

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