Clone:
MZ18-23C8
Type of antibody:
Primary antibodies
Isotype:
mouse IgG1κ
Applications:
FC, MICS, IF, IHC, ICC
Alternative names:
Entpd1, ATPDase, NTPDase-1, SPG64, EC3.6.1.5, gp80

Extended validation for CD39 Antibody, anti-human

Specificity

Epitope competition
In order to compare the epitope specificity of an antibody, the clone being used is compared with other known clones recognizing the same antigen in a competition assay.
Other clonesOverlap in epitope recognition with MZ18-23C8
REA739++
A1++
TU66++
Cells were incubated with an excess of purified unconjugated CD39 (MZ18-23C8) antibody followed by staining with fluorochrome-conjugated antibodies of other known clones against the same marker. Based on the fluorescence signal obtained, the clones were identified as recognizing completely overlapping (++), partially overlapping (+), or completely different epitopes (-) of the marker.

Sensitivity

Fixation data
To provide an indication on how an antibody performs after fixation of cells, in-house data on staining results before and after fixation with 3.7% formaldehyde using Miltenyi Biotec antibodies are provided. Different experimental settings may lead to different results.
No fixation
Post fixation
View details
Comparison of staining pattern on non-fixed and fixed cells using CD39 (MZ18-23C8). The performance of the antibody after fixation was tested by comparing the staining pattern on fresh (no fixation) versus fixed (post fixation) cells.
View details
Comparison of staining pattern on non-fixed and fixed cells using CD39 (MZ18-23C8). The performance of the antibody after fixation was tested by comparing the staining pattern on fresh (no fixation) versus fixed (post fixation) cells.
Comparison of staining pattern on non-fixed and fixed cells using CD39 (MZ18-23C8). The performance of the antibody after fixation was tested by comparing the staining pattern on fresh (no fixation) versus fixed (post fixation) cells.

Specifications for CD39 Antibody, anti-human

Overview

The CD39 antibody specifically recognizes the membrane-bound human CD39 antigen, which is expressed on an effector/memory-like subset of FoxP3
+
regulatory T cells. CD39 is an ectonucleotidase and catalyzes the hydrolysis of extracellular nucleotides, for example, ATP. In concert with CD73, which is an ecto-5’-nucleotidase, this can lead to the production of adenosine. High extracellular ATP concentrations indicate tissue injury and cell death and induce various pro-inflammatory responses in immune cells.
Through its enzymatic activity, CD39 can contribute to the suppressive function of regulatory T cells, for example, by eliminating extracellular ATP or by generating adenosine, which has suppressive effects on various immune cells.

Alternative names

Entpd1, ATPDase, NTPDase-1, SPG64, EC3.6.1.5, gp80

Detailed product information

Technical specifications

CloneMZ18-23C8
Clonalitymonoclonal
Isotypemouse IgG1κ
Isotype controlIsotype Control Antibody, mouse IgG1
Hostmouse
Type of antibodyPrimary antibodies
Specieshuman, non-human primate
Cross-reactivity
rhesus monkey (
Macaca mulatta
)
AntigenCD39
Alternative names of antigenEntpd1, ATPDase, NTPDase-1, SPG64, EC3.6.1.5, gp80
Molecular mass of antigen [kDa]58
Distribution of antigenB cells, dendritic cells, endothelial cells, Langerhans cells, macrophages, monocytes, NK cells, platelets, T cells, lymphocytes, placenta
Entrez Gene ID953
RRIDAB_2811318, AB_2660867, AB_1036210, AB_2660870, AB_2660871, AB_2660872, AB_2660873, AB_1036212, AB_1036208, AB_2811320

Reviews for CD39 Antibody, anti-human

CD39 Antibody of Good Quality from Miltenyi Biotec

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CD39-FITC, human (130-093-502)

Will buy and use it again. Recommendable!

References for CD39 Antibody, anti-human

Publications

  1. Borsellino, G. et al. (2007)
    Expression of ectonucleotidase CD39 by FoxP3
    +
    reg cells: hydrolysis of extracellular ATP and immune suppression.
    Blood 110: 1225-1232

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