Clone:
REAL719
Type of antibody:
Releasable fluorochromes, Primary antibodies, Recombinant antibodies
Applications:
MICS, IHC, IF
Alternative names:
T10, ADPRC 1

Specifications for CD38 Antibody, anti-human, REAdye_lease™

Overview

Clone REAL719 is an antibody fragment derived from the full CD38 antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity.
Clone REAL719 recognizes the human CD38 antigen, a single-chain type II transmembrane glycoprotein with enzymatic activity. It is present on the majority of hematopoietic cells, prevalent during early differentiation and activation processes. Terminally differentiated B cells (plasma cells) express CD38 brightly. Furthermore, CD38 is constitutively expressed in several tissues, for example brain, muscle, and kidney. CD38, a disease marker for human leukemias and myelomas, plays a role in the pathogenesis and outcome of human immunodeficiency virus infection and chronic lymphocytic leukemia, and controls insulin release and also the development of diabetes. Furthermore it catalyzes the synthesis and hydrolysis of cyclic ADP-ribose (cADPR) from NAD
+
to ADP-ribose which is essential for the regulation of intracellular Ca2
+
.
For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675).

Alternative names

T10, ADPRC 1

Detailed product information

Technical specifications

CloneREAL719
Clonalitymonoclonal
Isotype controlControl Antibody
Hostcell line
Type of antibodyReleasable fluorochromes, Primary antibodies, Recombinant antibodies
Specieshuman
AntigenCD38
Alternative names of antigenT10, ADPRC 1
Distribution of antigenB cells, leukocytes, lymphocytes, macrophages, myeloid cells, NK cells, red blood cells, T cells, basophils, plasma cells, thymocytes, pancreatic carcinoma cells, brain, kidney, ovary, placenta, skeletal muscle, tonsil

Resources for CD38 Antibody, anti-human, REAdye_lease™

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for CD38 Antibody, anti-human, REAdye_lease™

Publications

  1. Jackson, D. G. and Bell, J. I. (1990) Isolation of a cDNA encoding the human CD38 (T10) molecule, a cell surface glycoprotein with an unusual discontinuous pattern of expression during lymphocyte differentiation. J. Immunol. 144(7): 2811-2815
  2. Malavasi, F. et al. (2008) Evolution and function of the ADP ribosyl cyclase/CD38 gene family in physiology and pathology. Physiol. Rev. 88(3): 841-886
  3. Sathish, V. et al. (2014) Inflammation, caveolae and CD38-mediated calcium regulation in human airway smooth muscle. Biochim. Biophys. Acta 1843(2): 346-351

Related products for
CD38 Antibody, anti-human, REAdye_lease™

1 products available

Seems like you are coming from USA!
Do you want to visit our website in your country?