Clone:
REA594
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
CLL-1, MICL, DCAL-2

Specifications for CD371 (CLEC12A) Antibody, anti-mouse, REAfinity™

Overview

Clone REA594 recognizes the mouse CD371 (CLEC12A) antigen, a 30 kDa type II transmembrane protein with extracellular C-type lectin domains. CD371 (CLEC12A) is a member of the C-type lectin/C-type lectin–like domain (CTL/CTLD) superfamily which have a common protein fold and plays a role in cell adhesion, cell-cell signaling, glycoprotein turnover, inflammation, and immune response.CD371 expression is primarily found on granulocytes and monocytes but also on CD8
+
dendritic cells (DCs), plasmacytoid DCs, granulocytes, and B cells. It associates with the signaling phosphatases SHP-1 and SHP-2, but not with SHIP and is a negative regulator of granulocyte and monocyte function.
Additional information: Clone REA594 displays negligible binding to Fc receptors.

Alternative names

CLL-1, MICL, DCAL-2

Detailed product information

Technical specifications

CloneREA594
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenCD371 (CLEC12A)
Alternative names of antigenCLL-1, MICL, DCAL-2
Molecular mass of antigen [kDa]31
Distribution of antigenB cells, dendritic cells, granulocytes, monocytes
Entrez Gene ID232413
RRIDAB_2657814, AB_2657815, AB_2657816, AB_2657817, AB_2657818, AB_2657819, AB_2657820, AB_2657813

Resources for CD371 (CLEC12A) Antibody, anti-mouse, REAfinity™

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for CD371 (CLEC12A) Antibody, anti-mouse, REAfinity™

Publications

  1. Lahoud, M. H. et al. (2009) The C-type lectin Clec12A present on mouse and human dendritic cells can J. Immunol. 182(12): 7587-7594
  2. Chen, C. H. et al. (2006) Dendritic-cell-associated C-type lectin 2 (DCAL-2) alters dendritic-cell maturation and cytokine production. Blood 107(4): 1459-1467
  3. Marshall, A. S. et al. (2004) Identification and characterization of a novel human myeloid inhibitory C-type lectin-like receptor (MICL) that is predominantly expressed on granulocytes and monocytes. J. Biol. Chem. 279(15): 14792-14802

Related products for
CD371 (CLEC12A) Antibody, anti-mouse, REAfinity™

1 products available

Seems like you are coming from USA!
Do you want to visit our website in your country?