Clone:
REA492
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
CDw329, FOAP-9, OBBP-LIKE, Siglec-9

Specifications for CD329 (Siglec-9) Antibody, anti-human, REAfinity™

Overview

Clone REA492 recognizes the human CD329 antigen, a single-pass type I membrane protein also known as sialic acid-binding Ig-like lectin 9 (Siglec-9). Siglecs are characterized by an amino-terminal V-set immunoglobulin domain that binds to sialic acid residues, followed by a variable number of C2-set immunoglobulin-like domains. CD329 is expressed quite broadly among human blood leukocytes, being found on monocytes, neutrophils, B cells, NK cells, and minor subsets of T cells. Ligation of CD329 induced apoptosis in adult neutrophils in a caspase-dependent manner; in contrast, its activation under inflammatory conditions resulted in a caspase-independent autophagic type of cell death. These disparate actions implicate a unique role for CD329 in modulating cell survival under inflammatory and basal conditions.
Additional information: Clone REA492 displays negligible binding to Fc receptors.

Alternative names

CDw329, FOAP-9, OBBP-LIKE, Siglec-9

Detailed product information

Technical specifications

CloneREA492
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCD329 (Siglec-9)
Alternative names of antigenCDw329, FOAP-9, OBBP-LIKE, Siglec-9
Molecular mass of antigen [kDa]48
Distribution of antigenB cells, granulocytes, macrophages, monocytes, NK cells, T cells, leukocytes, lymphocytes, neutrophils
Entrez Gene ID27180
RRIDAB_2857611, AB_2857599, AB_2657546, AB_2657547, AB_2657548, AB_2657549, AB_2657550, AB_2657551, AB_2657552, AB_2657553

Resources for CD329 (Siglec-9) Antibody, anti-human, REAfinity™

Certificates

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References for CD329 (Siglec-9) Antibody, anti-human, REAfinity™

Publications

  1. Tanida, S. et al. (2013) Binding of the sialic acid-binding lectin, Siglec-9, to the membrane mucin, MUC1, induces recruitment of β-catenin and subsequent cell growth. J. Biol. Chem. 288(44): 31842-31852
  2. Zhang, J. Q. et al. (2000) Siglec-9, a novel sialic acid binding member of the immunoglobulin superfamily expressed broadly on human blood leukocytes. J. Biol. Chem. 275(29): 22121-22126
  3. Foussias, G. et al. (2000) Identification and molecular characterization of a novel member of the siglec family (SIGLEC9). Genomics 67(2): 171-178

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