Clone:
REA382
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
TLR6

Specifications for CD286 (TLR6) Antibody, anti-human, REAfinity™

Overview

Clone REA382 recognizes the human CD286 antigen, a single-pass type I membrane protein also known as toll-like receptor 6 (TLR6). CD286 is a member of the toll-like receptor family which plays a fundamental role in pathogen recognition and activation of innate immunity. Toll-like receptors are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize microbe-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various toll-like receptors exhibit different patterns of expression. CD286 is colocalized with TLR2 on the cell surface of monocytes/macrophages, dendritic cells, and granulocytes. It participates in the innate immune response to gram-positive bacteria and fungi and specifically recognizes diacylated and, to a lesser extent, triacylated lipopeptides. CD286 acts via MYD88 and TRAF6, leading to NFκB activation, cytokine secretio,n and the inflammatory response.
Additional information: Clone REA382 displays negligible binding to Fc receptors.

Alternative names

TLR6

Detailed product information

Technical specifications

CloneREA382
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCD286 (TLR6)
Alternative names of antigenTLR6
Molecular mass of antigen [kDa]88
Distribution of antigendendritic cells, macrophages, monocytes, granulocytes
Entrez Gene ID10333
RRIDAB_2656989, AB_2656990, AB_2656991, AB_2656992, AB_2656993, AB_2656994, AB_2656995, AB_2656988

Resources for CD286 (TLR6) Antibody, anti-human, REAfinity™

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for CD286 (TLR6) Antibody, anti-human, REAfinity™

Publications

  1. Takeuchi, O. et al. (1999) TLR6: A novel member of an expanding toll-like receptor family. Gene 231(1-2): 59-65
  2. Buwitt-Beckmann, U. et al. (2006) TLR1- and TLR6-independent recognition of bacterial lipopeptides. J. Biol. Chem. 281(14): 9049-9057
  3. Jin B. et al. (2012) The effects of TLR activation on T-cell development and differentiation. Clin. Dev. Immunol. 2012(836485): doi: 10.1155/2012/83

Related products for
CD286 (TLR6) Antibody, anti-human, REAfinity™

3 products available

Seems like you are coming from USA!
Do you want to visit our website in your country?