Clone:
REAL531
Type of antibody:
Releasable fluorochromes, Primary antibodies, Recombinant antibodies
Applications:
MICS, IHC, IF
Alternative names:
PDCD1, PD1, SLEB2, hPD-1, hPD-l, hSLE1

Specifications for CD279 (PD-1) Antibody, anti-human, REAdye_lease™

Overview

Clone REAL531 is an antibody fragment derived from the full CD279 (PD-1) antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity.
Clone REAL531 recognizes the human CD279 antigen, also known as PD-1 (programmed death-1) or PD1. CD279 is a 55 kDa transmembrane protein belonging to the CD28/CTLA-4 family. It is expressed on T cells, B cells, NK cells, activated myeloid cells, and dendritic cells. CD279 is not expressed on naive T cells but induced after activation and expressed on late, differentiated T cells. The ligands PD-L1 (CD274, also known as B7-H1) and PD-L2 (CD273, also known as B7-DC) belong to the B7 immunglobulin superfamily. PD-1 and its ligands mediate inhibitory signals that regulate the balance between T cell activation, tolerance, and immunopathology.
PD-1 is used as a marker for angioimmunoblastic lymphoma.
For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675).

Alternative names

PDCD1, PD1, SLEB2, hPD-1, hPD-l, hSLE1

Detailed product information

Technical specifications

CloneREAL531
Clonalitymonoclonal
Isotype controlControl Antibody
Hostcell line
Type of antibodyReleasable fluorochromes, Primary antibodies, Recombinant antibodies
Specieshuman
AntigenCD279 (PD1)
Alternative names of antigenPDCD1, PD1, SLEB2, hPD-1, hPD-l, hSLE1
Distribution of antigenB cells, monocytes, T cells, dendritic cells, myeloid cells, tumor cells, thymocytes, other, spleen, tonsil

References for CD279 (PD-1) Antibody, anti-human, REAdye_lease™

Publications

  1. Serriari, N.-E. et al. (2010) B and T lymphocyte attenuator is highly expressed on CMV-specific T cells during infection and regulates their function. J. Immunol. 185: 3140-3148
  2. Okazaki, T. and Honjo, T. (2007) PD-1 and PD-1 ligands: from discovery to clinical application. Int. Immunol. 19: 813-824
  3. Fife, B. T. et al. (2011) The role of the PD-1 pathway in autoimmunity and peripheral tolerance. Ann. N. Y. Acad. Sci. 1217: 45-59
  4. Keir, M. E. et al. (2008) PD-1 and its ligands in tolerance and immunity. Annu. Rev. Immunol. 26: 677-704

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