Clone:
REA247
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
TNFRSF14, ATAR, HVEA, HVEM, LIGHTR, TR2

Specifications for CD270 (HVEM) Antibody, anti-human, REAfinity™

Overview

Clone REA247 recognizes CD270, which is also known as HVEM and derives its name based on the ability of types 1 and 2 herpesvirus gD to bind to it for entry into the cell. CD270 is a type 1 transmembrane protein with a predicted molecular weight of 30 kDa and is a member of the TNFR superfamily. CD270 transmits both activating and inhibitory signals for, e.g., interaction with receptors such as BTLA or CD160 attenuates TCR-mediated signaling, whereas interaction with receptor LIGHT allows co-stimulation of T and B cells. Expression of CD270 is widely distributed and is found on hematopoietic cells such as dendritic cells, Tregs, monocytes, neutrophils, NK cells, B cells, and T cells, as well as on non-hematopoietic cells.
Additional information: Clone REA247 displays negligible binding to Fc receptors.

Alternative names

TNFRSF14, ATAR, HVEA, HVEM, LIGHTR, TR2

Detailed product information

Technical specifications

CloneREA247
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCD270 (HVEM)
Alternative names of antigenTNFRSF14, ATAR, HVEA, HVEM, LIGHTR, TR2
Molecular mass of antigen [kDa]26
Distribution of antigenB cells, dendritic cells, macrophages, T cells
Entrez Gene ID8764
RRIDAB_2656827, AB_2656828, AB_2656829, AB_2656830, AB_2656831, AB_2656832, AB_2656833, AB_2656836, AB_2656837, AB_2656826

Resources for CD270 (HVEM) Antibody, anti-human, REAfinity™

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for CD270 (HVEM) Antibody, anti-human, REAfinity™

Publications

  1. Ware, C. F. et al. (2009) Targeting the LIGHT-HVEM pathway. Adv. Exp. Med. Biol. 647: 146-155
  2. Pasero, C. et al. (2012) The HVEM network: new directions in targeting novel costimulatory/co-inhibitory molecules for cancer therapy. Curr. Opin. Pharmacol. 12(4): 478-485

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