Clone:
REA961
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
RANK, TRANCE-R, TNFRSF11A

Specifications for CD265 (RANK) Antibody, anti-mouse, REAfinity™

Overview

Clone REA961 recognizes the mouse CD265 antigen, also known as receptor activator of NF-κB (RANK) or tumor necrosis factor receptor superfamily member 11A (TNFRSF11A). RANK is the receptor for RANK-ligand (RANKL) which promotes osteoclast differentiation and activation. CD265 is also expressed on dendritic cells, skeletal muscle, thymus, liver, colon, small intestine, adrenal gland, mammary gland epithelial cells, prostate, vascular cells, and pancreas.
Additional information: Clone REA961 displays negligible binding to Fc receptors.

Alternative names

RANK, TRANCE-R, TNFRSF11A

Detailed product information

Technical specifications

CloneREA961
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenCD265 (RANK)
Alternative names of antigenRANK, TRANCE-R, TNFRSF11A
Molecular mass of antigen [kDa]63
Distribution of antigendendritic cells, epithelial cells, thymocytes, prostate, pancreas, liver, colon
Entrez Gene ID21934
RRIDAB_2727292, AB_2727323, AB_2727324, AB_2727293, AB_2727321, AB_2727291, AB_2727322

Resources for CD265 (RANK) Antibody, anti-mouse, REAfinity™

Certificates

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to search for Certificates of Analysis (CoA) by lot number.

References for CD265 (RANK) Antibody, anti-mouse, REAfinity™

Publications

  1. Anderson, D. M. et al. (1997) A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function. Nature 390(6656): 175-179
  2. Armstrong, A. P. et al. (2002) A RANK/TRAF6-dependent signal transduction pathway is essential for osteoclast cytoskeletal organization and resorptive function. J. Biol. Chem. 277(46): 44347-44356
  3. Liu, C. et al. (2010) Structural and functional insights of RANKL-RANK interaction and signaling. J. Immunol. 184(2): 6910-6919

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