Clone:
N2B2
Type of antibody:
Primary antibodies
Isotype:
rat IgG2aκ
Applications:
FC
Alternative names:
TNFSF10, APO2L, Ly81, TL2, TRAIL

Specifications for CD253 Antibody, anti-mouse

Overview

Clone N2B2 reacts with murine CD253, a type 2 transmembrane protein, also known as TNF-related apoptosis-inducing ligand (TRAIL), APO-2 ligand (APO-2L), or TNF ligand superfamily member 10 (TNFSF10). CD253 is expressed on a variety of cells of the innate and adaptive immune system, including natural killer (NK) cells. Often expression is induced or upregulated upon activation. CD253 can trigger apoptosis through trimerization of death receptor DR5 (TRAILR). The N2B2 antibody is reported to block CD253-mediated NK cell cytotoxicity
in vitro
.

Alternative names

TNFSF10, APO2L, Ly81, TL2, TRAIL

Detailed product information

Technical specifications

CloneN2B2
Clonalitymonoclonal
Isotyperat IgG2aκ
Isotype controlIsotype Control Antibody, rat IgG2a
Hostrat
Type of antibodyPrimary antibodies
Speciesmouse
AntigenCD253
Alternative names of antigenTNFSF10, APO2L, Ly81, TL2, TRAIL
Molecular mass of antigen [kDa]33
Distribution of antigenB cells, dendritic cells, microglia, NK cells, T cells, thymocytes, gut, kidney, lung, spleen
Entrez Gene ID22035
RRIDAB_2656684, AB_2656685, AB_2656686, AB_2656687, AB_2656683

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