Clone:
REA368
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC, MICS, IF, IHC
Alternative names:
SLC4A1, AE1

Specifications for CD233 Antibody, anti-human, REAfinity™

Overview

Clone REA368 recognizes the human CD233 antigen, a multi-pass membrane protein also known as anion exchange protein 1 (AE1) or solute carrier family 4 member 1 (SLC4A1). CD233 is a phylogenetically preserved transport protein responsible for mediating the electroneutral anion exchange of chloride for bicarbonate across a plasma membrane. It is the major integral membrane glycoprotein of the erythrocyte membrane and is required for the normal flexibility and stability of the erythrocyte membrane as well as for the normal erythrocyte shape via the interactions of its cytoplasmic domain with cytoskeletal proteins, glycolytic enzymes, and hemoglobin. CD233 mediates the chloride-bicarbonate exchange in the kidney, and is required for the normal acidification of the urine.
Additional information: Clone REA368 displays negligible binding to Fc receptors.

Alternative names

SLC4A1, AE1

Detailed product information

Technical specifications

CloneREA368
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCD233
Alternative names of antigenSLC4A1, AE1
Molecular mass of antigen [kDa]102
Distribution of antigenother
Entrez Gene ID652
RRIDAB_2728024, AB_2751868, AB_2751838, AB_2801814, AB_2801812, AB_2656485, AB_2656486, AB_2728047

References for CD233 Antibody, anti-human, REAfinity™

Publications

  1. Rungaldier, S. et al. (2013) Stomatin interacts with GLUT1/SLC2A1, band 3/SLC4A1, and aquaporin-1 in human erythrocyte membrane domains. Biochim. Biophys. Acta 1828(3): 956-966
  2. Barneaud-Rocca, D. et al. (2013) Structural model of the anion exchanger 1 (SLC4A1) and identification of transmembrane segments forming the transport site. J. Biol. Chem. 288(37): 26372-26384
  3. Al-Samir, S. et al. (2013) Activity and distribution of intracellular carbonic anhydrase II and their effects on the transport activity of anion exchanger AE1/SLC4A1. J. Physiol. 591(20): 4963-4982

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