Clone:
REA1095
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
IL18R1, CD218a, CDw218a, IL-1Rrp, IL18RA, IL1RRP

Specifications for CD218 (IL-18Rα) Antibody, anti-human, REAfinity™

Overview

Clone REA1095 recognizes the CD218 antigen, which is also known as interleukin-18 receptor alpha (IL-18Rα) chain. IL-18 receptor is an heterodimeric receptor complex, and composed of the IL-18Rα chain and the IL-1 receptor accessory protein-like (IL-1RacPL) or IL-18Rβ chain. CD218 represents the ligand-binding chain, whereas IL-18Rβ is suggested to assist in the formation of a high affinity complex and mediates intracellular signals. IL-18R is expressed on a variety of cells including macrophages, neutrophils, natural killer (NK) cells, endothelial, and smooth muscle cells and an upregulated expression is observed on naive T cells, T helper cell type 1 (Tʜ1) cells, and B cells, in the presence IL-12.
Additional information: Clone REA1095 displays negligible binding to Fc receptors.

Alternative names

IL18R1, CD218a, CDw218a, IL-1Rrp, IL18RA, IL1RRP

Detailed product information

Technical specifications

CloneREA1095
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCD218 (IL-18Rα)
Alternative names of antigenIL18R1, CD218a, CDw218a, IL-1Rrp, IL18RA, IL1RRP
Molecular mass of antigen [kDa]60
Distribution of antigenB cells, endothelial cells, macrophages, NK cells, naive T cells, Th1 cells, smooth muscle
Entrez Gene ID8809
RRIDAB_2733595, AB_2733724, AB_2733725, AB_2733303, AB_2733304, AB_2733177, AB_2733178, AB_2733081, AB_2733082, AB_2733474, AB_2733475, AB_2733594

References for CD218 (IL-18Rα) Antibody, anti-human, REAfinity™

Publications

  1. Nakamura, S. et al. (2000) Expression and responsiveness of human interleukin-18 receptor (IL-18R) on hematopoietic cell lines. Leukemia 14(6): 1052-1059
  2. Kim, S. H. et al. (2001) Functional reconstitution and regulation of IL-18 activity by the IL-18Rβ chain. J. Immunol. 166: 148-154

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