Clone:
1560
Type of antibody:
Primary antibodies
Isotype:
rat IgG2bκ
Applications:
FC
Alternative names:
Procr, CCCA, CCD41, EPCR

Specifications for CD201 (EPCR) Antibody, anti-mouse

Overview

Clone 1560 recognizes the mouse CD201 antigen, a single-pass type I membrane protein which is also known as endothelial protein C receptor (EPCR). CD201 is strongly expressed in the endothelial cells of arteries and veins in heart and lung, and less intensely in capillaries in the lung and skin. It is also expressed on a subset of neutrophils, monocytes, and several tumor cells. It was demonstrated that murine CD201 is expressed at high levels within the bone marrow by hematopoietic stem cells (HSC). Bone marrow cells isolated on the basis of CD201 expression alone are highly enriched for hematopoietic reconstitution activity, showing levels of engraftment
in vivo
. The major role of CD201 is anticoagulation. CD201 binds to protein C with high affinity and augments the activation of protein C by the thrombin-thrombomodulin complex. Another important functional aspect of CD201 is its role in many pathophysiologic processes, such as inflammation responses to infection, trauma, hematopoiesis, and autoimmune response. Deletion of the CD201 gene in mice has been reported to lead to embryonic lethality before embryonic day 10. Overexpression of CD201 results in resistance to formation of thrombin in response to a procoagulant stimulus and decreased susceptibility to endotoxin-induced septic shock. Mice with severe CD201 deficiency have been reported to have no measurable influence on an arterial thrombosis model but have a more severe coagulation response to endotoxemia.

Alternative names

Procr, CCCA, CCD41, EPCR

Detailed product information

Technical specifications

Clone1560
Clonalitymonoclonal
Isotyperat IgG2bκ
Isotype controlIsotype Control Antibody, rat IgG2b
Hostrat
Type of antibodyPrimary antibodies
Speciesmouse
AntigenCD201 (EPCR)
Alternative names of antigenProcr, CCCA, CCD41, EPCR
Molecular mass of antigen [kDa]25
Distribution of antigenendothelial cells, monocytes, neutrophils
Entrez Gene ID19124
RRIDAB_2656141, AB_2656142, AB_2656143, AB_2656140

References for CD201 (EPCR) Antibody, anti-mouse

Publications

  1. Balazs, B. et al. (2006) Endothelial protein C receptor (CD201) explicitly identifies hematopoietic stem cells in murine bone marrow Blood 107(6): 2317-2321
  2. Zheng, X. et al. (2007) Effects of membrane and soluble EPCR on the hemostatic balance and endotoxemia in mice. Blood 109(3): 1003-1009
  3. Fukudome, K. et al. (1995) Molecular cloning and expression of murine and bovine endothelial cell protein C/activated protein C receptor (EPCR). The structural and functional conservation in human, bovine, and murine EPCR. J. Biol. Chem. 270(10): 5571-5577

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