Clone:
1A5
Type of antibody:
Primary antibodies
Isotype:
mouse IgG1κ
Applications:
FC, MICS, IF, IHC
Alternative names:
CD33L2, OB-BP2, OBBP2, Siglec-5

Specifications for CD170 (Siglec-5) Antibody, anti-human

Overview

Clone 1A5 recognizes the CD170 antigen, a single-pass transmembrane protein member of the immunoglobulin superfamily, also known as sialic acid-binding Ig-like lectin 5 (siglec-5). CD170 is expressed on neutrophils, monocytes, dendritic cells, and subsets of tissue macrophages. It contains two tyrosine-based motifs in its cytoplasmic tail implicating signaling functions and forms a 140 kDa dimer on the cell surface. Tyrosine phosphorylation of CD170 leads to recruitment of the tyrosine phosphatases SHP-1 and SHP-2, which in turn efficiently inhibits FcεRI-mediated calcium fluxing and serotonin release. CD170 binds α 2-3– and α 2-6–linked sialic acid as well as glycophorin A, and is involved in cell adhesion.

Alternative names

CD33L2, OB-BP2, OBBP2, Siglec-5

Detailed product information

Technical specifications

Clone1A5
Clonalitymonoclonal
Isotypemouse IgG1κ
Isotype controlIsotype Control Antibody, mouse IgG1
Hostmouse
Type of antibodyPrimary antibodies
Specieshuman, non-human primate
Cross-reactivity
chimpanzee (
Pan troglodytes
)
,
bonobo (
Pan paniscus
)
AntigenCD170 (Siglec-5)
Alternative names of antigenCD33L2, OB-BP2, OBBP2, Siglec-5
Distribution of antigenmacrophages, monocytes, dendritic cells
RRIDAB_2655570, AB_2655571, AB_2655572, AB_2655573, AB_2655574, AB_2655575, AB_2655576, AB_2655577, AB_2655578, AB_2655579, AB_2655580, AB_2655569

References for CD170 (Siglec-5) Antibody, anti-human

Publications

  1. Erickson-Miller, C. L. et al. (2003) Characterization of Siglec-5 (CD170) expression and functional activity of anti-Siglec-5 antibodies on human phagocytes. Exp. Hematol. 31(5): 382-388
  2. Cornish, A. L. et al. (1998) Characterization of Siglec-5, a novel glycoprotein expressed on myeloid cells related to CD33. Blood 92(6): 2123-2132
  3. Avril, T. et al. (2005) Siglec-5 (CD170) can mediate inhibitory signaling in the absence of immunoreceptor tyrosine-based inhibitory motif phosphorylation. J. Biol. Chem. 280: 19843-19851

Related products for
CD170 (Siglec-5) Antibody, anti-human

3 products available

Seems like you are coming from USA!
Do you want to visit our website in your country?