Clone:
REA589
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
FCGR3B, Fc-gamma RIIIb, FCG3, FCGR3, FcR-10, FcRIII, FcRIIIb

Specifications for CD16b Antibody, anti-human, REAfinity™

Overview

Clone REA589 recognizes the human CD16b antigen, a glycosylphosphatidylinositol-anchored protein known as low affinity immunoglobulin gamma Fc region receptor III-B. CD16 is expressed in two different isoforms, FcγRIIIa (CD16a), which is found on human NK cells, macrophages, and mast cells, and FcγRIIIb (CD16b) Fc receptors, that bind to the Fc portion of IgG antibodies which mediates NK cell activating. CD16b is polymorphic and has two codominant alleles that are related to Neutrophil Antigen 1 (NA1) and Neutrophil Antigen 2 (NA2). Clone REA589 is present on polymorphonuclear leukocytes (neutrophils) expressing the NA1 molecule.
Additional information: Clone REA589 displays negligible binding to Fc receptors.

Alternative names

FCGR3B, Fc-gamma RIIIb, FCG3, FCGR3, FcR-10, FcRIII, FcRIIIb

Detailed product information

Technical specifications

CloneREA589
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCD16b
Alternative names of antigenFCGR3B, Fc-gamma RIIIb, FCG3, FCGR3, FcR-10, FcRIII, FcRIIIb
Molecular mass of antigen [kDa]21
Distribution of antigenmacrophages, mast cells, NK cells, leukocytes
Entrez Gene ID2215
RRIDAB_2802047, AB_2655561, AB_2655562, AB_2655563, AB_2655564, AB_2655565, AB_2655566, AB_2655567, AB_2655568, AB_2802053

References for CD16b Antibody, anti-human, REAfinity™

Publications

  1. Ravetch, J. V. et al. (1989) Alternative membrane forms of Fc gamma RIII(CD16) on human natural killer cells and neutrophils. Cell type-specific expression of two genes that differ in single nucleotide substitutions. J. Exp. Med. 170(2): 481-497
  2. Peltz, G. A. et al. (1989) Human Fc gamma RIII: cloning, expression, and identification of the chromosomal locus of two Fc receptors for IgG. Proc. Natl. Acad. Sci. U.S.A. 86(3): 1013-1017
  3. Gessner, J. E. et al. (1995) The human low affinity immunoglobulin G Fc receptor III-A and III-B genes. Molecular characterization of the promoter regions. J. Biol. Chem. 270(3): 1350-1361
  4. Monti, M. et al. (2017) Integrin-dependent cell adhesion to neutrophil extracellular traps through engagement of fibronectin in neutrophil-like cells. PLoS One 12

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