Clone:
REA519
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
PVR, HVED, PVS, Taa1, TAGE4, mE4, NECL-5

Specifications for CD155 Antibody, anti-mouse, REAfinity™

Overview

Clone REA519 recognizes the mouse CD155 antigen, which is a 70 kDa type I transmembrane glycoprotein in the immunoglobulin superfamily. CD155, also known as poliovirus receptor (PVR), belongs to a large family of Ig molecules called nectins and nectin-like proteins, which mediate cell-cell adhesion, cell migration, and serve as entry receptors for viruses. CD155 and its family member CD112 (nectin-2) are the ligands for the activating cell-surface receptor DNAM-1 on CD8
+
T cells and natural killer (NK) cells. Mouse CD155 is found on a wide variety of cells of hematopoietic origin, on CD4
+
CD8
+
thymocytes, regulatory T cells, other activated T cells, NKT cells, and at cell junctions on the primary vascular endothelial cells.
Additional information: Clone REA519 displays negligible binding to Fc receptors.

Alternative names

PVR, HVED, PVS, Taa1, TAGE4, mE4, NECL-5

Detailed product information

Technical specifications

CloneREA519
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenCD155
Alternative names of antigenPVR, HVED, PVS, Taa1, TAGE4, mE4, NECL-5
Molecular mass of antigen [kDa]45
Distribution of antigenendothelial cells, T cells, T helper cells, NKT cells
Entrez Gene ID52118
RRIDAB_2655282, AB_2655283, AB_2655284, AB_2655285, AB_2655286, AB_2655287, AB_2655288, AB_2655289, AB_2655290, AB_2655281

References for CD155 Antibody, anti-mouse, REAfinity™

Publications

  1. Fuchs, A. et al. (2004) Cutting Edge: CD96 (Tactile) promotes NK cell-target cell adhesion by interacting with the poliovirus receptor (CD155). J. Immunol. 172: 3994-3998
  2. Tahara-Hanaoka, S. et al. (2006) Tumor rejection by the poliovirus receptor family ligands of the DNAM-1 (CD226) receptor. Blood 107: 1491-1496
  3. Seth, S. et al. (2007) The murine pan T cell marker CD96 is an adhesion receptor for CD155 and nectin-1. Biochem. Biophys. Res. Commun. 364(4): 959-965

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