Clone:
REA964
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
Thrombomodulin, Fetomodulin, TM, BDCA-3

Specifications for CD141 (BDCA-3) Antibody, anti-mouse, REAfinity™

Overview

Clone REA964 recognizes the mouse CD141 antigen, which is also known as BDCA-3, thrombomodulin, or fetomodulin. CD141 is a type I cell surface glycoprotein expressed mainly on endothelial cells. CD141 functions as a specific endothelial cell receptor for thrombin. This complex cleaves protein C and the thrombin activatable fibrinolysis Inhibitor (TAFI), initiating an anticoagulant pathway.
Additional information: Clone REA964 displays negligible binding to Fc receptors.

Alternative names

Thrombomodulin, Fetomodulin, TM, BDCA-3

Detailed product information

Technical specifications

CloneREA964
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenCD141 (BDCA-3)
Alternative names of antigenThrombomodulin, Fetomodulin, TM, BDCA-3
Molecular mass of antigen [kDa]60
Distribution of antigenendothelial cells, macrophages, monocytes
Entrez Gene ID21824
RRIDAB_2727343, AB_2727309, AB_2727344, AB_2727310, AB_2727347, AB_2727345, AB_2727311, AB_2727346, AB_2727342, AB_2727308

References for CD141 (BDCA-3) Antibody, anti-mouse, REAfinity™

Publications

  1. Dittman, W. A. et al. (1988) The structure and function of mouse thrombomodulin. Phorbol myristate acetate stimulates degradation and synthesis of thrombomodulin without affecting mRNA levels in hemangioma cells. J. Biol. Chem. 263(30): 15815-15822
  2. Bajzar, L. et al. (1996) TAFI, or plasma procarboxypeptidase B, couples the coagulation and fibrinolytic cascades through the thrombin-thrombomodulin complex. J. Biol. Chem. 271(28): 16603-16608
  3. Isermann, B. et al. (2001) Endothelium-specific loss of murine thrombomodulin disrupts the protein C anticoagulant pathway and causes juvenile-onset thrombosis. J. Clin. Invest. 108(4): 537-546

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