Clone:
REA254
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
TNFSF9, 4-1BBL, CD137 ligand, Tumor necrosis factor ligand superfamily member 9 (TNFSF9)

Specifications for CD137L (4-1BBL) Antibody, anti-human, REAfinity™

Overview

Clone REA254 recognizes the CD137L antigen, a type II transmembrane glycoprotein belonging to the TNF superfamily, which is also known as 4-1BB ligand or tumor necrosis factor ligand superfamily member 9. CD137L is expressed on a variety of antigen-presenting cells, including dendritic cells (DCs), B cells, and macrophages as well as on activated T Lymphocytes. CD137L cross-links its receptor, CD137, which is expressed on activated T cells, and co-stimulates T cell activities. Signaling through interaction with CD137 by soluble CD137L has been shown to cause T cell–expansion, cytokine induction, and upregulation of antiapoptotic genes, and to prevent activation-induced cell death. In monocytes, macrophages, and DCs, CD137L signaling induces activation, migration, survival, and differentiation. The role of CD137 signaling has been studied in several autoimmune processes, including rheumatoid arthritis, experimental autoimmune encephalomyelitis, and systemic lupus erythematosus.
Additional information: Clone REA254 displays negligible binding to Fc receptors.

Alternative names

TNFSF9, 4-1BBL, CD137 ligand, Tumor necrosis factor ligand superfamily member 9 (TNFSF9)

Detailed product information

Technical specifications

CloneREA254
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCD137L (4-1BBL)
Alternative names of antigenTNFSF9, 4-1BBL, CD137 ligand, Tumor necrosis factor ligand superfamily member 9 (TNFSF9)
Molecular mass of antigen [kDa]27
Distribution of antigenB cells, T cells, macrophages, monocytes, dendritic cells
Entrez Gene ID8744
RRIDAB_2751596, AB_2783949, AB_2783948, AB_2857744, AB_2857738, AB_2655007, AB_2655008, AB_2751642

Resources for CD137L (4-1BBL) Antibody, anti-human, REAfinity™

References for CD137L (4-1BBL) Antibody, anti-human, REAfinity™

Publications

  1. Alderson, M. R. et al. (1994) Molecular and biological characterization of human 4-1BB and its ligand. Eur. J. Immunol. 24(9): 2219-2227
  2. Shao, Z. et al. (2011) CD137 ligand, a member of the tumor necrosis factor family, regulates immune responses via reverse signal transduction. J. Leukoc. Biol. 89: 21-29
  3. Wang, C. et al. (2009) Immune regulation by 4-1BB and 4-1BBL: complexities and challenges. Immunol. Rev. 229(1): 192-215
  4. Vinay, D. S. et al. (2012) Immunotherapy of cancer with 4-1BB. Mol. Cancer Ther. 11: 1062-1070

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