Clone:
A2F10
Type of antibody:
Primary antibodies
Isotype:
rat IgG2aκ
Applications:
FC
Alternative names:
FLT3, FLK-2, Ly72, wmfl, Flt3/Flk2, STK-1

Specifications for CD135 (FLT3) Antibody, anti-mouse

Overview

Clone A2F10 binds the 150 kDa surface protein Fms-like tyrosine kinase receptor 3 (FLT3), also known as FLK-2/CD135. CD135 has functional and structural homology to the class-III-receptor tyrosine kinases that include the M-CSF-, KIT-, and PDGF-receptors. The receptor is expressed on progenitor cells in adult bone marrow, thymus, brain, testis, and placenta. All hematopoietic cells develop from CD135 negative hematopoietic stem cells (HSCs) through CD135 positive progenitor cells. In synergy with other growth factors like G-CSF, GM-CSF, SCF, and IL-3, ligation of CD135 with FLT3 ligand promotes the proliferation and differentiation of primitive hematopoietic stem cells. As a result early B cell lineage differentiation as well as expansion of monocytes and immature dendritic cells are stimulated.

Alternative names

FLT3, FLK-2, Ly72, wmfl, Flt3/Flk2, STK-1

Detailed product information

Technical specifications

CloneA2F10
Clonalitymonoclonal
Isotyperat IgG2aκ
Isotype controlIsotype Control Antibody, rat IgG2a
Hostrat
Type of antibodyPrimary antibodies
Speciesmouse
AntigenCD135 (FLT3)
Alternative names of antigenFLT3, FLK-2, Ly72, wmfl, Flt3/Flk2, STK-1
Molecular mass of antigen [kDa]110
Distribution of antigenstem cells, B cells, cardiac cells, hematopoietic stem and progenitor cells, CNS cells, bone marrow, brain, lung, spleen
Entrez Gene ID14255
RRIDAB_2654981, AB_2654978, AB_2654979, AB_2654980, AB_2654977

References for CD135 (FLT3) Antibody, anti-mouse

Publications

  1. Ogawa, M. et al. (1998) Flt3/Flk-2 and c-Kit are not essential for the proliferation of B lymphoid progenitor cells in the bone marrow of the adult mouse. Exp. Hematol. 26(6): 478-488
  2. Hannum, C. et al. (1994) Ligand for FLT3/FLK2 receptor tyrosine kinase regulates growth of haematopoietic stem cells and is encoded by variant RNAs. Nature 368(6472): 643-648
  3. Boyer, S. W. et al. (2011) All hematopoietic cells develop from hematopoietic stem cells through Flk2/Flt3-positive progenitor cells. Cell Stem Cell 9(1): 64-73
  4. Böiers, C. et al. (2010) Expression and role of FLT3 in regulation of the earliest stage of normal granulocyte-monocyte progenitor development. Blood 115(24): 5061-5068
  5. Waskow, C. et al. (2008) The receptor tyrosine kinase Flt3 is required for dendritic cell development in peripheral lymphoid tissues. Nat. Immunol. 9(6): 676-683
  6. Auffray, C. et al. (2009)
    CX
    3
    CR1
    +
    CD115
    +
    CD135
    +
    common macrophage/DC precursors and the role of CX
    3
    CR1 in their response to inflammation.
    J. Exp. Med. 206(3): 595-606

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