Clone:
A3C6E2
Type of antibody:
Primary antibodies
Isotype:
mouse IgG1κ
Applications:
FC, MICS, IF, IHC
Alternative names:
c-kit, KIT, PBT, SCFR

Specifications for CD117 Antibody, anti-human

Overview

CD117, also known as c-kit or SCF receptor, is a 145 kDa receptor tyrosine kinase that is involved in stem cell signaling, activation, and proliferation. The CD117 antigen is expressed on about 1–3% of mononuclear cells from peripheral blood mononuclear cells (PBMCs) or cord blood, and on up to 10% of bone marrow cells. CD117 is further expressed on basophils, myeloid dendritic cells, TCRα/β
+
T cells, CD19
+
B cells, and CD56
+
NK cells, as well as on mast cells, melanocytes, and AML (acute myeloid leukemia) blasts.
Clone A3C6E2 recognizes a different epitope than clone AC126 and may interfere with SCF-binding. It is therefore not recommended for indirect cell isolation, but is optimal for flow cytometric analysis of cells separated with the CD117 MicroBead Kit, human.

Alternative names

c-kit, KIT, PBT, SCFR

Detailed product information

Technical specifications

CloneA3C6E2
Clonalitymonoclonal
Isotypemouse IgG1κ
Isotype controlIsotype Control Antibody, mouse IgG1
Hostmouse
Type of antibodyPrimary antibodies
Specieshuman
AntigenCD117
Alternative names of antigenc-kit, KIT, PBT, SCFR
Molecular mass of antigen [kDa]107
Distribution of antigenB cells, endothelial cells, fibroblasts, mast cells, megakaryocytes, NK cells, red blood cells, T cells, stem cells, cancer stem cells, hematopoietic stem and progenitor cells, leukemia cells, bone marrow, brain, kidney, liver, lung
Entrez Gene ID3815
RRIDAB_2733757, AB_2733334, AB_2733335, AB_2801680, AB_2801677, AB_2733756

References for CD117 Antibody, anti-human

Publications

  1. Kubo, H. et al. (2008) Increased cardiac myocyte progenitors in failing human hearts. Circulation 118: 649-657
  2. Berglund, E. et al. (2013)
    Evidence for Ca
    2+
    -regulated ATP release in gastrointestinal stromal tumors.
    Exp. Cell Res. 319(8): 1229-1238
  3. Bühring, H. J. et al. (1991) The product of the proto-oncogene c-kit (P145c-kit) is a human bone marrow surface antigen of hematopoietic precursor cells which is expressed on a subset of acute non-lymphoblastic cells. Leukemia 5: 854-860

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