Clone:
LMM741
Type of antibody:
Primary antibodies
Isotype:
mouse IgG1κ
Applications:
FC
Alternative names:
CSF-3R, G-CSFR

Specifications for CD114 Antibody, anti-human

Overview

Clone LMM741 binds the receptor for granulocyte colony stimulating factor (G-CSFR, CSF3), a 130–150 kDa type I transmembrane glycoprotein of the class 1 cytokine receptor gene family also known as CD114. Ligand binding leads to homodimerization and subsequent signal transduction involving the JAK-STAT pathway. CD114 is expressed by neutrophils at all stages of differentiation but also found on monocytes, endothelial cells, mature platelets, trophoblasts, and placenta.

Alternative names

CSF-3R, G-CSFR

Detailed product information

Technical specifications

CloneLMM741
Clonalitymonoclonal
Isotypemouse IgG1κ
Isotype controlIsotype Control Antibody, mouse IgG1
Hostmouse
Type of antibodyPrimary antibodies
Specieshuman
AntigenCD114
Alternative names of antigenCSF-3R, G-CSFR
Molecular mass of antigen [kDa]90
Distribution of antigenendothelial cells, granulocytes, monocytes, platelets, neutrophils, placenta
Entrez Gene ID1441
RRIDAB_2654548, AB_2654549

Resources for CD114 Antibody, anti-human

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for CD114 Antibody, anti-human

Publications

  1. Gibbs, K. D. et al. (2011) Single-cell phospho-specific flow cytometric analysis demonstrates biochemical and functional heterogeneity in human hematopoietic stem and progenitor compartments. Blood (117): 4226-4233
  2. Liongue, C. et al. (2009) Granulocyte colony-stimulating factor receptor: stimulating granulopoiesis and much more. Int. J. Biochem. Cell Biol. 12(41): 2372-2375
  3. Ward, A. C. (2007) The role of the granulocyte colony-stimulating factor receptor (G-CSF-R) in disease. Front Biosci. 12: 608-618
  4. Piper, M. G. et al. (2010) Neutrophil elastase downmodulates native GCSFR expression and granulocyte-macrophage colony formation. J. Inflamm. 7(1): 5

Related products for
CD114 Antibody, anti-human

2 products available

Seems like you are coming from USA!
Do you want to visit our website in your country?