Clone:
REA511
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC
Alternative names:
ACT-2, LAG-1, HC21, MIP-1-beta, PAT 744, Protein H400, SIS-gamma

Specifications for CCL4 (MIP-1β) Antibody, anti-human, REAfinity™

Overview

Clone REA511 recognizes the human C-C motif chemokine 4 (CCL4) antigen, a secreted protein, which is also known as macrophage inflammatory protein 1 beta (MIP-1β). CCL4 is a chemoattractant for natural killer cells, monocytes, and a variety of other immune cells. It is expressed primarily by T cells, B cells, and monocytes after antigen or mitogen stimulation. The functional receptor for CCL4 beta has been identified as CCR5. CCL4 is a proinflammatory chemokine that both promotes leukocyte accumulation in various inflammatory conditions and contributes to protective immunity against human immunodeficiency virus type 1 (HIV-1). CCL4 is the most potent chemoattractant of a CD4
+
CD25
+
T cell population, which is a characteristic phenotype of regulatory T cells. Depletion of either regulatory T cells or CCL4 results in a deregulated humoral response, which culminates in the production of autoantibodies. This suggests that the recruitment of regulatory T cells to B cells and antigen-presenting cells (APCs) by CCL4 plays a central role in the normal initiation of T cell and humoral responses, and failure to do this leads to autoimmune activation.
Additional information: Clone REA511 displays negligible binding to Fc receptors.

Alternative names

ACT-2, LAG-1, HC21, MIP-1-beta, PAT 744, Protein H400, SIS-gamma

Detailed product information

Technical specifications

CloneREA511
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCCL4 (MIP-1β)
Alternative names of antigenACT-2, LAG-1, HC21, MIP-1-beta, PAT 744, Protein H400, SIS-gamma
Molecular mass of antigen [kDa]8(refers to MIP-1-beta(1-69))
Distribution of antigenB cells, monocytes, T cells
Entrez Gene ID6351
RRIDAB_2857772, AB_2651385, AB_2651386, AB_2857781

Resources for CCL4 (MIP-1β) Antibody, anti-human, REAfinity™

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for CCL4 (MIP-1β) Antibody, anti-human, REAfinity™

Publications

  1. Bystry, R. S. et al. (2001) B cells and professional APCs recruit regulatory T cells via CCL4. Nat. Immunol. 2(12): 1126-1132
  2. Guan, E. et al. (2002) Natural truncation of the chemokine MIP-1 beta /CCL4 affects receptor specificity but not anti-HIV-1 activity. J. Biol. Chem. 277(35): 32348-32352
  3. Baixeras, E. et al. (1990) Cloning and expression of a lymphocyte activation gene (LAG-1). Mol. Immunol. 27(11): 1091-1102

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