Clone:
REA248
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC
Alternative names:
GDCF-2, HC11, HSMCR30, MCAF, MCP-1, Scya2, SMC-CF

Specifications for CCL2 (MCP-1) Antibody, anti-human, REAfinity™

Overview

Clone REA248 recognizes the monocyte chemotactic protein 1 (MCP-1) antigen, a member of the beta (C-C) chemokine subfamily, which is also known as C-C motif chemokine 2 (CCL2) or monocyte chemotactic and activating factor (MCAF). MCP-1 is anchored in the plasma membrane of endothelial cells and is primarily secreted by monocytes, macrophages, and dendritic cells. Platelet-derived growth factor is a major inducer of the MCP-1 gene. MCP-1 recruits monocytes, memory T cells, and dendritic cells to the sites of inflammation produced by either tissue injury or infection. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis, or atherosclerosis.
Additional information: Clone REA248 displays negligible binding to Fc receptors.

Alternative names

GDCF-2, HC11, HSMCR30, MCAF, MCP-1, Scya2, SMC-CF

Detailed product information

Technical specifications

CloneREA248
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman, non-human primate
Cross-reactivity
rhesus monkey (
Macaca mulatta
)
,
cynomolgus monkey (
Macaca fascicularis
)
AntigenCCL2 (MCP-1)
Alternative names of antigenGDCF-2, HC11, HSMCR30, MCAF, MCP-1, Scya2, SMC-CF
Molecular mass of antigen [kDa]9
Distribution of antigenmacrophages, monocytes, astrocytes, epithelial cells, endothelial cells, fibroblasts, microglia
Entrez Gene ID6347
RRIDAB_2651364, AB_2651365, AB_2651366, AB_2651363

Resources for CCL2 (MCP-1) Antibody, anti-human, REAfinity™

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for CCL2 (MCP-1) Antibody, anti-human, REAfinity™

Publications

  1. Yoshimura, T. and Leonard, E. J. (1991) Human monocyte chemoattractant protein-1 (MCP-1). Adv. Exp. Med. Biol. 305: 47-56
  2. Paavola, C. D. et al. (1998) Monomeric monocyte chemoattractant protein-1 (MCP-1) binds and activates the MCP-1 receptor CCR2B. J. Biol. Chem. 273(50): 33157-33165
  3. Xia, M. and Sui, Z. (2009) Recent developments in CCR2 antagonists. Expert Opin. Ther. Pat. 19(3): 295-303

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