Clone:
REA397
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC
Alternative names:
REL

Specifications for c-Rel Antibody, anti-mouse, REAfinity™

Overview

Clone REA397 recognizes the mouse c-Rel antigen, a 65 kDa member of the NF-κB family of eukaryotic transcription factors, which also includes the proteins RelA (p65), RelB, NF-κB1 (p105/p50), and NF-κB2 (p100/p52). NF-κB transcription factors can form various homo- and heterodimers possessing unique specificities in regulating target gene expression. While RelA-containing dimers are present in most cell types, c-Rel complexes are predominately found in cells of hematopoietic origin. In T cell lymphocytes, certain genes essential for immune function such as interleukin 2 (IL-2) and FoxP3 are directly regulated by c-Rel. Additionally, c-Rel-dependent IL-12 and IL-23 transcription by macrophages and dendritic cells (DCs) is crucial for T cell differentiation and effector functions. Accordingly, c-Rel expression in T cells and antigen-presenting cells controls a delicate balance between tolerance and immunity.
Additional information: Clone REA397 displays negligible binding to Fc receptors.

Alternative names

REL

Detailed product information

Technical specifications

CloneREA397
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
Antigenc-Rel
Alternative names of antigenREL
Molecular mass of antigen [kDa]65
Distribution of antigenT cells, lymphocytes, dendritic cells, macrophages
Entrez Gene ID19696
RRIDAB_2651455, AB_2651456, AB_2811682

References for c-Rel Antibody, anti-mouse, REAfinity™

Publications

  1. Gilmore, T. D. et al. (2004) The c-Rel transcription factor and B-cell proliferation: a deal with the devil. Oncogene 23(13): 2275-2286
  2. Grumont, R. J. et al. (1990) The murine c-rel proto-oncogene encodes two mRNAs the expression of which is modulated by lymphoid stimuli. Oncogene 5(4): 245-254
  3. Gonzalez-Perez, G. et al. (2017)
    Gastrointestinal microbiome dysbiosis in infant mice alters peripheral CD8
    +
    T cell receptor signaling.
    Front Immunol 8: 265
  4. Gonzalez-Perez, G. and Lamousé-Smith, E. S. (2017)
    Gastrointestinal microbiome dysbiosis in infant mice alters peripheral CD8
    +
    T cell receptor signaling.
    Front Immunol 8(8): 265
  5. Visekruna, A. et al. (2012) A key role for NF-κB transcription factor c-Rel in T-lymphocyte-differentiation and effector functions. Clin. Dev. Immunol. 2012: 239368

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