Clone:
REA358
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC
Alternative names:
ANON2, BULN2

Specifications for BDNF Antibody, anti-human, REAfinity™

Overview

Clone REA358 recognizes the human brain-derived neurotrophic factor (BDNF) antigen, a secreted protein which is a member of the neurotrophin family of growth factors and related to the canonical nerve growth factor. BDNF is highly expressed in hippocampus, amygdala, cerebral cortex, and cerebellum. It is also expressed in heart, lung, skeletal muscle, testis, prostate, and placenta. During development, BDNF promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. It participates in axonal growth, pathfinding, and in the modulation of dendritic growth and morphology. BDNF is a major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation, long-term depression, certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability. Binding of BDNF to its receptor TrkB elicits various intracellular signaling pathways, including MAPK/ERK, PLCg, and PI3K pathways.
Additional information: Clone REA358 displays negligible binding to Fc receptors.

Alternative names

ANON2, BULN2

Detailed product information

Technical specifications

CloneREA358
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenBDNF
Alternative names of antigenANON2, BULN2
Molecular mass of antigen [kDa]13
Distribution of antigenother, brain, heart, lung, prostate, skeletal muscle, testicle, placenta
Entrez Gene ID627
RRIDAB_2651276, AB_2651277, AB_2651274

Resources for BDNF Antibody, anti-human, REAfinity™

Certificates

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References for BDNF Antibody, anti-human, REAfinity™

Publications

  1. Jones, K. R. et al. (1990) Molecular cloning of a human gene that is a member of the nerve growth factor family. Proc. Natl. Acad. Sci. U.S.A. 87(20): 8060-8064
  2. Numakawa, T. et al. (2010) BDNF function and intracellular signaling in neurons. Histol. Histopathol. 25(2): 237-258
  3. Yoshii, A. et al. (2010) Postsynaptic BDNF-TrkB signaling in synapse maturation, plasticity, and disease. Dev. Neurobiol. 70(5): 304-322

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