<br>ISCT 2021 New Orleans Virtual


ISCT 2021 New Orleans Virtual

Corporate Symposium and Roundtable 

Expanding the possibilities in cell therapy manufacturing

At Miltenyi Biotec, we are committed to supporting clinical innovators and manufacturers with solutions and services that enable scalable clinical translation of novel cell and gene therapies. Watch our symposium, recorded at the ISCT 2021 New Orleans Virtual, and hear from your peers how they are expanding the possibilities to advance cell therapy. In our recorded roundtable discussion we delve into the question of whether there are platforms that significantly shorten clinical readiness for CAR T therapies. 

Recorded talks

Corporate Symposium

Expanding possibilities for advancing cell therapy

In this symposium you have the chance to meet Boris Fehse who established a mRNA electroporation protocol for the automated production of CCR5-edited CD4+ T cells on the CliniMACS Prodigy® to prevent HIV infection. Sandy Pelletier will outline her approach to isolate tumor-reactive T cells from solid tumors using the MACSQuant® Tyto® Cell Sorter. Last but not least, Moonsoo M. Jin presents his work with affinity-tuned CAR T cells to target solid tumors with high-level antigen expression.
 

Presenters
 

Clinical scale CCR5 knockout in primary T cells in the CliniMACS Prodigy

Speaker: Boris Fehse
University Medical Center Hamburg-Eppendorf, Germany 

Abstract
Knocking out the HIV co-receptor CCR5 by gene editing is promising clinical strategy to protect CD4+ T helper cells from HIV infection. We have developed a GMP-compatible mRNA electroporation protocol for delivery of our high-efficiency CCR5-specific TALEN using the CliniMACS Prodigy System. The automated process reliably produced clinical-scale amounts of CCR5-edited CD4+ T cells (>1.5x109 cells with >60% CCR5 editing) within 12 days.
 

About Boris Fehse
Prof. Dr. Boris Fehse is Professor for Cell and Gene Therapy and Head of the Research Department Cell and Gene Therapy within the Department of Stem Cell Transplantation of the University Medical Center Hamburg-Eppendorf (UKE), Germany. Prior to joining UKE, he held an appointment as Professor for Experimental Pediatric Oncology and Hematology at the University Hospital of the Johann Wolfgang Goethe University Frankfurt, Germany. Prof. Fehse graduated in Biomedicine at the Russian State Medical University of Moscow, Russia (German M.D. in Theroretical Medicine) and obtained his Ph.D. in Molecular Biology at the Heinrich-Pette-Institute and the University of Hamburg. He did his postdoctoral training at the Bone Marrow Transplantation Center of the UMC Hamburg and spent a research period abroad at the NIH in Bethesda, USA, after having received a grant of the German American Academic Council (GAAC).  

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Harnessing the power of tumor-infiltrating lymphocytes

Speaker: Sandy Pelletier
CHUM Research Center, Montreal, Canada

Abstract
Although cell therapy for the treatment of cancer has shown success, many challenges persist. Our approach includes successfully isolating tumor-reactive T cells from solid tumors using the MACSQuant Tyto – a GMP-compliant flow cytometry-based cell sorter – with the purpose of using these cells for tumor-infiltrating lymphocyte adoptive cell transfer
 

About Sandy Pelletier
Sandy Pelletier, Ph.D., is Scientific Coordinator of the Adoptive Cell Transfer (ACT) Immunotherapy Program at CHUM Research Center, Montreal, Canada, where she also worked as Research Associate from 2013 to 2016. Her current responsibilities include coordinating the development of a phase I/II clinical trial, setting up new clean room for GMP manufacturing, and generating and analyzing pre-clinical data. Sandy Pelletier obtained her Ph.D. from the Université de Montréal, Canada.  

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Affinity-tuned CAR T to treat tumors with overexpressed antigens: Phase I study against advanced thyroid cancer

Speaker: Moonsoo M. Jin
Molecular Imaging Innovations Institute (MI3), New York, USA          

Abstract
We developed affinity-tuned ICAM-1 targeting CAR T cells to be selective to tumors with overexpressed ICAM-1. Our CAR has SSTR2 that allows PET/CT monitoring of CAR T distribution in patients. I’ll also talk about CAR T manufacturing, general strategy of affinity-tuning, and ways to elevate CAR T activity.
 

About Moonsoo M. Jin                 
Moonsoo M. Jin, Ph.D., is a biomedical engineer with expertise and training in molecular and cellular engineering, nanoparticles for imaging and drug delivery, and whole-body imaging techniques. Using multiscale biomedical tools, his research is focused on developing technology concerned with therapy and diagnosis of cancer and inflammation-associated diseases. He currently serves as director of the Molecular Imaging Innovations Institute (MI3), New York, USA.

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Roundtable

Are there platforms that significantly shorten clinical readiness for CAR T therapies?

Join Kunal Patel, Process Engineering Manager at Miltenyi Biotec, amongst others panelists and delve into the question of whether there are platforms that significantly shorten clinical readiness for CAR T therapies.

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