Clone:
REAL1238
Type of antibody:
Releasable fluorochromes, Primary antibodies, Recombinant antibodies
Applications:
MICS, IHC, IF
Alternative names:
TACSTD2, GA733-1, M1S1, EGP-1

Specifications for TROP2 Antibody, anti-human, REAdye_lease™

Overview

Clone REAL1238 is an antibody fragment derived from the full TROP2 antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity.
Clone REAL1238 recognizes the human TROP2 antigen, a type I membrane glycoprotein also known as TACSTD2 (Tumor-associated calcium signal transducer 2). TROP2 acts as a signal transducer and may be involved in regulating the growth of carcinoma cells. TROP2 is strongly expressed by a variety of human carcinomas, but also on trophoblasts and epithelial cells.
For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675).

Alternative names

TACSTD2, GA733-1, M1S1, EGP-1

Detailed product information

Technical specifications

CloneREAL1238
Clonalitymonoclonal
Isotype controlControl Antibody
Hosthuman cell line
Type of antibodyReleasable fluorochromes, Primary antibodies, Recombinant antibodies
Specieshuman
AntigenTROP2
Alternative names of antigenTACSTD2, GA733-1, M1S1, EGP-1
Distribution of antigenepithelial cells, tumor cells, pancreatic carcinoma cells, other, placenta

Resources for TROP2 Antibody, anti-human, REAdye_lease™

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for TROP2 Antibody, anti-human, REAdye_lease™

Publications

  1. Fornaro, M. et al. (1995) Cloning of the gene encoding Trop-2, a cell-surface glycoprotein expressed by human carcinomas. Int. J. Cancer 62(5): 610-618
  2. Ripani, E. et al. (1998) Human Trop-2 is a tumor-associated calcium signal transducer. Int. J. Cancer 76(5): 671-676
  3. Cubas, R. et al. (2010) Trop2 expression contributes to tumor pathogenesis by activating the ERK MAPK pathway. Mol. Cancer 9
  4. Shvartsur, A. et al. (2015) Trop2 and its overexpression in cancers: regulation and clinical/therapeutic implications. Genes Cancer 6(3-4): 84-105

Related products for
TROP2 Antibody, anti-human, REAdye_lease™

1 products available

Seems like you are coming from USA!
Do you want to visit our website in your country?