CD86 antibodies, human

CD86 antibodies, human

Clone: REA968 | Dilution: 1:50
Clone REA968 recognizes the human CD86 antigen, also known as B7-2 or B70, which is an 80 kDa molecule and a member of the immunoglobulin superfamily. Together with CD80 (B7-1) it belongs to the B7 family of co-stimulatory molecules. CD86 is expressed on activated B and T cells, dendritic cells, and monocytes/macrophages. The interaction of CD86 with its ligands CD28 and CD152 (CTLA- 4) plays a critical role in induction and regulation of immune responses, e.g., cross-talk between T and B cells, T cell costimulation, or immunoglobulin class-switching. Binding of CD86 to CD28 on T cells results in transduction of costimulatory signals for activation or proliferation of T cells or cytokine production.
Additional information: Clone REA968 displays negligible binding to Fc receptors.

Alternative names

B7-2, B70, CD28LG2, LAB72

Technical specifications

  • Antigen: CD86
  • Clone: REA968
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: B7-2, B70, CD28LG2, LAB72
  • Entrez Gene ID: 942
  • Molecular mass of antigen [kDa]: 35
  • Distribution of antigen: B cells, dendritic cells, Langerhans cells, macrophages, monocytes, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, VioBlue, PE-Vio615, PE-Vio770, APC-Vio770, PerCP-Vio700, VioBright 515, Biotin
  • Selected references

    1. Azuma, M. et al. (1993) B70 antigen is a second ligand for CTLA-4 and CD28. Nature 366(6450): 76-79
    2. Engel, P. et al. (1994) The B7-2 (B70) costimulatory molecule expressed by monocytes and activated B lymphocytes is the CD86 differentiation antigen. Blood 84(5): 1402-1407
    3. Lanier, L. L. et al. (1995) CD80 (B7) and CD86 (B70) provide similar costimulatory signals for T cell proliferation, cytokine production, and generation of CTL. J. Immunol. 154(1): 97-105
Product options: 19
130-116-262

CD86-FITC, human

for 30
tests
(1)
GBP 60.00
130-116-159

CD86-FITC, human

for 100
tests
(1)
GBP 155.00
130-116-263

CD86-PE, human

for 30
tests
(1)
GBP 70.00
130-116-160

CD86-PE, human

for 100
tests
(1)
GBP 180.00
130-116-264

CD86-APC, human

for 30
tests
(1)
GBP 70.00
130-116-161

CD86-APC, human

for 100
tests
(1)
GBP 180.00
for 30
tests
(1)
GBP 75.00
for 100
tests
(1)
GBP 190.00
for 30
tests
(1)
GBP 80.00
for 100
tests
(1)
GBP 195.00
for 30
tests
(1)
GBP 80.00
for 100
tests
(1)
GBP 195.00
for 100
tests
(1)
GBP 195.00
for 30
tests
(1)
GBP 80.00
for 100
tests
(1)
GBP 195.00
for 30
tests
(1)
GBP 105.00
for 100
tests
(1)
GBP 245.00
for 30
tests
(1)
GBP 60.00
for 100
tests
(1)
GBP 155.00