CD41/CD61 antibodies, human

CD41/CD61 antibodies, human

Clone: REA607 | Dilution: 1:11
Clone REA607 recognizes the CD41/CD61 complex, also known as gpIIb/IIIa complex or integrin αIIbβ3. This cell adhesion molecule is a α/β transmembrane heterodimer of the ubiquitous integrin superfamily which is expressed by megakaryocytes and platelets. The CD41/CD61 complex plays an significant role in hemostasis and is also involved in fibrinogen binding and platelet aggregation.
Additional information: Clone REA607 displays negligible binding to Fc receptors.

Alternative names

gpIIb/IIIa complex, integrin αIIbβ3

Technical specifications

  • Antigen: CD41/CD61
  • Clone: REA607
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: gpIIb/IIIa complex, integrin αIIbβ3
  • Entrez Gene ID: 3674, 3690
  • Distribution of antigen: megakaryocytes, platelets
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, VioGreen, PE-Vio770, Biotin
  • Selected references

    1. Naik, U. P. et al. (1997) Identification of a novel calcium-binding protein that interacts with the integrin alphaIIb cytoplasmic domain. J. Biol. Chem. 272(8): 4651-4654
    2. Corbel, C. et al. (2005) (alpha)IIb integrin, a novel marker for hemopoietic progenitor cells. Int. J. Dev. Biol. 49(2-3): 279-284
    3. Podolnikova, N. P. et al. (2014) The interaction of integrin αIIbβ3 with fibrin occurs through multiple binding sites in the αIIb β-propeller domain. J. Biol. Chem. 289(4): 2371-2383
Product options: 8
for 30
tests
(1)
GBP 60.00
for 100
tests
(1)
GBP 150.00
for 30
tests
(1)
GBP 75.00
for 100
tests
(1)
GBP 185.00
for 30
tests
(1)
GBP 80.00
for 100
tests
(1)
GBP 190.00
for 30
tests
(1)
GBP 60.00
for 100
tests
(1)
GBP 150.00

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