CD39 antibodies, human

CD39 antibodies, human

Clone: REA739 | Dilution: 1:50
Clone REA739 recognizes the 70–100 kDa membrane-bound human CD39 molecule, which is expressed on an effector/memory-like subset of FoxP3
+
regulatory T cells. CD39 is an ectonucleotidase and catalyzes the hydrolysis of extracellular nucleotides, for example, ATP. Together with CD73, which is an ecto-5’-nucleotidase, this can lead to the production of adenosine. High extracellular ATP concentrations indicate tissue injury and cell death and induce various pro-inflammatory responses in immune cells.
Through its enzymatic activity, CD39 can contribute to the suppressive function of regulatory T cells, for example, by eliminating extracellular ATP or by generating adenosine, which has suppressive effects on various immune cells.
Additional information: Clone REA739 displays negligible binding to Fc receptors.

Alternative names

Entpd1, ATPDase, NTPDase-1, SPG64, EC3.6.1.5, gp80

Technical specifications

  • Antigen: CD39
  • Clone: REA739
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: Entpd1, ATPDase, NTPDase-1, SPG64, EC3.6.1.5, gp80
  • Entrez Gene ID: 953
  • Molecular mass of antigen [kDa]: 58
  • Cross-reactivity:
    rhesus monkey (
    Macaca mulatta
    )
  • Distribution of antigen: T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: VioBright FITC, PE, APC, PE-Vio615, PE-Vio770, APC-Vio770, Biotin
  • Selected references

    1. Maliszewski, C. R. et al. (1994) The CD39 lymphoid cell activation antigen. Molecular cloning and structural characterization. J. Immunol. 153(8): 3574-3583
    2. Kaczmarek, E. et al. (1996) Identification and characterization of CD39/vascular ATP diphosphohydrolase. J. Biol. Chem. 271(51): 33116-33122
    3. Borsellino, G. et al. (2007)
      Expression of ectonucleotidase CD39 by FoxP3
      +
      reg cells: hydrolysis of extracellular ATP and immune suppression.
      Blood 110: 1225-1232
Product options: 14
for 30
tests
(1)
GBP 80.00
for 100
tests
(1)
GBP 190.00
130-110-788

CD39-PE, human

for 30
tests
(1)
GBP 70.00
130-110-650

CD39-PE, human

for 100
tests
(1)
GBP 175.00
130-110-789

CD39-APC, human

for 30
tests
(1)
GBP 70.00
130-110-651

CD39-APC, human

for 100
tests
(1)
GBP 175.00
for 30
tests
(1)
GBP 80.00
for 100
tests
(1)
GBP 190.00
for 30
tests
(1)
GBP 80.00
for 100
tests
(1)
GBP 190.00
for 30
tests
(1)
GBP 80.00
for 100
tests
(1)
GBP 190.00
for 30
tests
(1)
GBP 60.00
for 100
tests
(1)
GBP 150.00

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