CD370 (CLEC9A) antibodies, human

CD370 (CLEC9A) antibodies, human

Clone: REA976 | Dilution: 1:50
Clone REA976 recognizes the human CD370 antigen, also known as C-type lectin domain family 9 member A (CLEC9A). CD370 is a type II transmembrane glycoprotein member of 241 amino acids with a predicted molecular mass of ~30 kDa. It is also known as DNGR-1 and is expressed on BDCA-3
+
myeloid dendritic cells from peripheral blood and lymphoid tissues. CD370 acts as a receptor for necrotic cells and plays an important role in cross-presentation.
Additional information: Clone REA976 displays negligible binding to Fc receptors.

Alternative names

DNGR-1, C-type lectin family member 9A

Technical specifications

  • Antigen: CD370 (CLEC9A)
  • Clone: REA976
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: DNGR-1, C-type lectin family member 9A
  • Entrez Gene ID: 283420
  • Molecular mass of antigen [kDa]: 27
  • Distribution of antigen: dendritic cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, Biotin
  • Selected references

    1. Poulin, L. F. et al. (2010)
      Characterization of human DNGR-1
      +
      BDCA3
      +
      leukocytes as putative equivalents of mouse CD8 alpha
      +
      dendritic cells.
      J. Exp. Med. 207(6): 1261-1271
    2. Sancho, D. et al. (2008) Tumor therapy in mice via antigen targeting to a novel, DC-restricted C-type lectin. J. Clin. Invest. 118(6): 2098-2110
    3. Sancho, D. et al. (2009) Identification of a dendritic cell receptor that couples sensing of necrosis to immunity. Nature 458(7240): 899-903
Product options: 8
for 30
tests
(1)
GBP 60.00
for 100
tests
(1)
GBP 150.00
for 30
tests
(1)
GBP 70.00
for 100
tests
(1)
GBP 175.00
for 30
tests
(1)
GBP 70.00
for 100
tests
(1)
GBP 175.00
for 30
tests
(1)
GBP 60.00
for 100
tests
(1)
GBP 150.00

Related products

2 products available