CD357 (GITR) antibodies, human

CD357 (GITR) antibodies, human

Clone: DT5D3 | Dilution: 1:50
CD357, also known as glucocorticoid-induced tumor necrosis factor receptor–related protein (GITR) or TNFRSF18, is an inducible type I transmembrane protein and member of the tumor necrosis factor receptor (TNFR) superfamily.
CD357 is expressed at low levels on thymocyte subsets, resting T cells, B cells, macrophages, and at high levels on CD4
+
CD25
+
regulatory T cells (Tregs). Upon activation, expression on CD4
+
and CD8
+
T cells is upregulated. Triggering of CD357 has been described to modulate Treg function and costimulate effector T cells. Stimulation of T cells through CD357 can abrogate the inhibitory function of Tregs. It is hypothesized that CD357 has a role in the maintenance of immunological self tolerance, and mouse models of autoimmune disease suggest that CD357 activation may break self-tolerance and induce autoimmunity.

Alternative names

TNFRSF18, AITR, GITR-D

Technical specifications

  • Antigen: CD357 (GITR)
  • Clone: DT5D3
  • Isotype: mouse IgG1κ
  • Isotype control: Mouse IgG1 – isotype control antibodies
  • Alternative names of antigen: TNFRSF18, AITR, GITR-D
  • Entrez Gene ID: 8784
  • Molecular mass of antigen [kDa]: 24
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: APC, PE, Biotin
  • Selected references

    1. Nocentini, G. et al. (1997) A new member of the tumor necrosis factor/nerve growth factor receptor family inhibits T cell receptor-induced apoptosis. Proc. Natl. Acad. Sci. U.S.A. 94: 6216-6221
    2. Nocentini, G. et al. (2007) GITR/GITRL: more than an effector T cell co-stimulatory system. Eur. J. Immunol. 37: 1165-1169
    3. Gurney, A. L. et al. (1999) Identification of a new member of the tumor necrosis factor family and its receptor, a human ortholog of mouse GITR. Curr. Biol. 9: 215-218
Product options: 6
for 30
tests
(1)
GBP 70.00
for 100
tests
(1)
GBP 175.00
for 30
tests
(1)
GBP 70.00
for 100
tests
(1)
GBP 175.00
for 30
tests
(1)
GBP 60.00
for 100
tests
(1)
GBP 150.00

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