CD33 antibodies, human

CD33 antibodies, human

Clone: REA775 | Dilution: 1:50
Clone REA775 recognizes the human CD33 antigen, a 67 kDa glycoprotein belonging to the sialoadhesin superfamily. The CD33 antigen is highly expressed on human monocytes but weakly on granulocytes and some – but not all – myeloid dendritic cells. The CD33 antigen is also found on myeloid progenitor cells (CFU-GEMM, CFU GM, CFU-G, BFU-E) but is not expressed on lymphocytes, platelets, erythrocytes, or primitive hematopoietic stem cells.
Additional information: Clone REA775 displays negligible binding to Fc receptors.

Alternative names

Siglec-3, p67, My9

Technical specifications

  • Antigen: CD33
  • Clone: REA775
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: Siglec-3, p67, My9
  • Entrez Gene ID: 945
  • Molecular mass of antigen [kDa]: 38
  • Cross-reactivity:
    cynomolgus monkey (
    Macaca fascicularis
    )
    ,
    rhesus monkey (
    Macaca mulatta
    )
  • Distribution of antigen: basophils, dendritic cells, granulocytes, Langerhans cells, leukemia cells, macrophages, mast cells, monocytes, myeloid cells, NK cells, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, VioBlue, VioGreen, PE-Vio615, PE-Vio770, APC-Vio770, PerCP-Vio700, VioBright 515, Biotin
  • Selected references

    1. Simmons, D. et al. (1988) Isolation of a cDNA encoding CD33, a differentiation antigen of myeloid progenitor cells. J. Immunol. 141(8): 2797-2800
    2. Bernstein, I. D. et al. (1987)
      Treatment of acute myeloid leukemia cells
      in vitro
      with a monoclonal antibody recognizing a myeloid differentiation antigen allows normal progenitor cells to be expressed.
      J. Clin. Invest. 79(4): 1153-1159
    3. Hernández-Caselles, T. et al. (2006) A study of CD33 (SIGLEC-3) antigen expression and function on activated human T and NK cells: two isoforms of CD33 are generated by alternative splicing. J. Leukoc. Biol. 79(1): 46-58
Product options: 22
130-111-135

CD33-FITC, human

for 30
tests
(1)
GBP 60.00
130-111-018

CD33-FITC, human

for 100
tests
(1)
GBP 150.00
130-111-136

CD33-PE, human

for 30
tests
(1)
GBP 70.00
130-111-019

CD33-PE, human

for 100
tests
(1)
GBP 175.00
130-111-137

CD33-APC, human

for 30
tests
(1)
GBP 70.00
130-111-020

CD33-APC, human

for 100
tests
(1)
GBP 175.00
for 30
tests
(1)
GBP 75.00
for 100
tests
(1)
GBP 185.00
for 30
tests
(1)
GBP 75.00
for 100
tests
(1)
GBP 185.00
for 30
tests
(1)
GBP 80.00
for 100
tests
(1)
GBP 190.00
for 30
tests
(1)
GBP 80.00
for 100
tests
(1)
GBP 190.00
for 30
tests
(1)
GBP 80.00
for 100
tests
(1)
GBP 190.00
for 30
tests
(1)
GBP 80.00
for 100
tests
(1)
GBP 190.00
for 30
tests
(1)
GBP 100.00
for 100
tests
(1)
GBP 240.00
for 30
tests
(1)
GBP 60.00
for 100
tests
(1)
GBP 150.00

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