CD32 antibodies, human

CD32 antibodies, human

Clone: 2E1 | Dilution: 1:11
CD32, also known as FcγRII, is a 40 kDa low affinity receptor for the Fc fragment of aggregated IgG. Due to alternative splicing three different isoforms of CD32 are expressed on hematopoietic cells: FcRIIA, FcRIIB, and FcRIIC. The cytoplasmic domains of FcRIIA and FcRIIC contain an activatory ITAM motif whereas FcRIIB is an inhibitory receptor containing an ITIM motif. Different isoforms of CD32 are expressed on B cells, monocytes, dendritic cells, granulocytes, and platelets. The monoclonal antibody 2E1 recognizes all isoforms of CD32 without blocking the binding of immune complexes.

Alternative names

FCGR2A, FCGR2B, FCGR2C, FcγRII

Technical specifications

  • Antigen: CD32
  • Clone: 2E1
  • Isotype: mouse IgG2aκ
  • Isotype control: Mouse IgG2a – isotype control antibodies
  • Alternative names of antigen: FCGR2A, FCGR2B, FCGR2C, FcγRII
  • Entrez Gene ID: 2212
  • Molecular mass of antigen [kDa]: 31
  • Cross-reactivity:
    rhesus monkey (
    Macaca mulatta
    )
    ,
    cynomolgus monkey (
    Macaca fascicularis
    )
    , baboon, horse
  • Distribution of antigen: B cells, basophils, dendritic cells, endothelial cells, eosinophils, granulocytes, Langerhans cells, leukocytes, lymphocytes, macrophages, monocytes, myeloid cells, neutrophils, NK cells, placenta, plasma cells, platelets
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, VioBlue, PE-Vio770, APC-Vio770, Biotin, FITC
  • Selected references

    1. Båve, U. et al. (2003) Fc gamma RIIa is expressed on natural IFN-alpha-producing cells (plasmacytoid dendritic cells) and is required for the IFN-alpha production induced by apoptotic cells combined with lupus IgG. J. Immunol. 171(6): 3296-3302
    2. Van Den Herik-Oudijk, I. E. et al. (1994) Functional analysis of human Fc gamma RII (CD32) isoforms expressed in B lymphocytes. J. Immunol. 152(2): 574-585
Product options: 8
130-097-518

CD32-FITC, human

for 100
tests
(1)
GBP 150.00
130-097-521

CD32-PE, human

for 100
tests
(1)
GBP 175.00
130-097-525

CD32-APC, human

for 100
tests
(1)
GBP 175.00
for 100
tests
(1)
GBP 185.00
for 100
tests
(1)
GBP 190.00
for 30
tests
(1)
GBP 80.00
for 100
tests
(1)
GBP 190.00
for 100
tests
(1)
GBP 150.00

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