CD319 (CRACC) antibodies, human

CD319 (CRACC) antibodies, human

Clone: REA150 | Dilution: 1:50
Clone REA150 recognizes CD319, which is a single-pass type I transmembrane protein. CD319 belongs to the SLAM-related receptors (SRRs) family, a subgroup of the CD2 family of Ig-like receptors. Expression of CD319 is found on activated B lymphocytes, natural killer (NK) cells, CD8
T lymphocytes, and mature dendritic cells. The cytoplasmic domain of CD319 contains immunoreceptor tyrosine-based switch motifs (ITSMs), which provide the docking sites for recruitment of small SH2-containing adapter proteins, such as SH2D1A/SLAM-associated protein (SAP) and EWS activated transcript 2 (EAT-2). CD319 displays homophilic interaction and is involved in mediating NK cell cytotoxicity, in the absence of an inhibitory receptor engagement.
Additional information: Clone REA150 displays negligible binding to Fc receptors.

Alternative names


Technical specifications

  • Antigen: CD319 (CRACC)
  • Clone: REA150
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: SLAMF7, 19A, CRACC, CS1
  • Entrez Gene ID: 57823
  • Molecular mass of antigen [kDa]: 35
  • Distribution of antigen: NK cells, lymphocytes, dendritic cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE
  • Selected references

    1. Lee, J. K. et al. (2007) CS1 (CRACC, CD319) induces proliferation and autocrine cytokine expression on human B lymphocytes. J. Immunol. 179(7): 4672-4678
    2. Tassi, I. et al. (2005) The cytotoxicity receptor CRACC (CS-1) recruits EAT-2 and activates the PI3K and phospholipase C signaling pathways in human NK cells. J. Immunol. 175: 7996-8002
    3. Lee, J. K. et al. (2004) Molecular and functional characterization of a CS1 (CRACC) splice variant expressed in human NK cells that does not contain immunoreceptor tyrosine-based switch motifs. Eur. J. Immunol. 34(10): 2791-2799
Product options: 2
for 30
GBP 70.00
for 100
GBP 180.00

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