CD192 (CCR2) antibodies, mouse

CD192 (CCR2) antibodies, mouse

Clone: REA538 | Dilution: 1:50
Clone REA538 recognizes the mouse CD192 antigen, a multi-pass membrane protein, which is also known as C-C chemokine receptor type 2 (CCR2) or monocyte chemoattractant protein 1 receptor (MCP-1-R). CD192 is a receptor for the CCL2, CCL7, and CCL12 chemokines and plays important roles in the recruitment of monocytes, macrophages, and T cells. It transduces a signal by increasing intracellular calcium ion levels. In mice CD192 is homogeneously expressed on monocytes and on 2–15% of T cells, closely resembling the expression pattern in humans. The percentage of CD192
T cells is almost two times higher in the Tʜ1-prone mouse strain C57BL/6 than in the Tʜ2-prone strain BALB/c. The strain-dependent expression correlates to a reduced Tʜ1 response described in CD192-deficient mice.
Additional information: Clone REA538 displays negligible binding to Fc receptors.

Alternative names

CCR2, CC-CKR-2, CCR2B, Ckr2, CKR2A, Ckr2b, Cmkbr2, mJe-r, MCP-1-R

Technical specifications

  • Antigen: CD192 (CCR2)
  • Clone: REA538
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: CCR2, CC-CKR-2, CCR2B, Ckr2, CKR2A, Ckr2b, Cmkbr2, mJe-r, MCP-1-R
  • Entrez Gene ID: 12772
  • Molecular mass of antigen [kDa]: 43
  • Distribution of antigen: macrophages, monocytes, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: APC, PE-Vio770, PE
  • Selected references

    1. Mack, M. et al. (2001) Expression and characterization of the chemokine receptors CCR2 and CCR5 in mice. J. Immunol. 166(7): 4697-4704
    2. Majmudar, M. D. et al. (2013) Monocyte-directed RNAi targeting CCR2 improves infarct healing in atherosclerosis-prone mice. Circulation 127(20): 2038-2046
    3. Kurihara, T. et al. (1996) Cloning and functional expression of mCCR2, a murine receptor for the C-C chemokines JE and FIC. J. Biol. Chem. 271(20): 11603-11607
Product options: 3
30 µg in 200 µL (1)
GBP 50.00
30 µg in 200 µL (1)
GBP 50.00
30 µg in 200 µL (1)
GBP 70.00

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