CD184 (CXCR4) antibodies, human

CD184 (CXCR4) antibodies, human

Clone: REA649 | Dilution: 1:50
Clone REA649 recognizes the human CD184 antigen, a multi-pass membrane protein, also known as C-X-C chemokine receptor type 4 (CXCR4), leukocyte-derived seven transmembrane domain receptor (LESTR), or fusin. CD184 is ubiquitously expressed on blood and tissue cells. It mediates chemotaxis in mature and progenitor blood cells and is important for B lymphopoiesis, myelopoiesis, and cardiogenesis. CD184 exclusively interacts with the endogenous ligand CXCL12. Binding of CXCL12 transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Although CXCL12 is the only known chemokine that binds CD184, recent studies suggest that extracellular ubiquitin also acts as an immune modulator through CD184-mediated signaling. CD184 is a coreceptor for HIV entry by promoting Env-mediated fusion of the virus.
Additional information: Clone REA649 displays negligible binding to Fc receptors.

Alternative names

CXCR4, Fusin, LESTR, FB22, HM89, LCR1, LAP-3, NPYRL

Technical specifications

  • Antigen: CD184 (CXCR4)
  • Clone: REA649
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: CXCR4, Fusin, LESTR, FB22, HM89, LCR1, LAP-3, NPYRL
  • Entrez Gene ID: 7852
  • Molecular mass of antigen [kDa]: 40
  • Cross-reactivity:
    cynomolgus monkey (
    Macaca fascicularis
    )
    ,
    rhesus monkey (
    Macaca mulatta
    )
    ,
    african green monkey (
    Chlorocebus aethiops
    )
    , baboon,
    chimpanzee (
    Pan troglodytes
    )
    ,
    sooty mangabey (
    Cercocebus atys
    )
  • Distribution of antigen: B cells, brain, dendritic cells, endothelial cells, epithelial cells, granulocytes, heart, hematopoietic stem cells, kidney, leukocytes, liver, lung, lymphocytes, megakaryocytes, mesenchymal stem cells, monocytes, myeloid cells, neurons, pancreatic carcinoma cells, placenta, platelets, skeletal muscle, spleen, T cells, thymocytes
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: VioBright FITC, PE, APC-Vio770, VioBright 515, APC
  • Selected references

    1. Ichiyama, K. et al. (2003) A duodenally absorbable CXC chemokine receptor 4 antagonist, KRH-1636, exhibits a potent and selective anti-HIV-1 activity. Proc. Natl. Acad. Sci. U.S.A. 100: 4185-4190
    2. McKnight, A. et al. (1997) Inhibition of human immunodeficiency virus fusion by a monoclonal antibody to a coreceptor (CXCR4) is both cell type and virus strain dependent. J. Virol. 71(2): 1692-1696
    3. McKnight, A. et al. (1997) Inhibition of human immunodeficiency virus fusion by a monoclonal antibody to a coreceptor (CXCR4) is both cell type and virus strain dependent. J. Virol. 71(2): 1692-1696
    4. Berger, E. A. et al. (1999) Chemokine receptors as HIV-1 coreceptors: roles in viral entry, tropism, and disease. Annu. Rev. Immunol. 17: 657-700
    5. Chen, Y. et al. (2015) CXCR4 inhibition in tumor microenvironment facilitates anti-programmed death receptor-1 immunotherapy in sorafenib-treated hepatocellular carcinoma in mice. Hepatology 61(5): 1591-1602
    6. Loetscher, M. et al. (1994) Cloning of a human seven-transmembrane domain receptor, LESTR, that is highly expressed in leukocytes. J. Biol. Chem. 269(1): 232-237
    7. Loetscher, P. et al. (2000) Chemokines and their receptors in lymphocyte traffic and HIV infection. Adv. Immunol. 74: 127-180
    8. Chatterjee, S. et al. (2014) The intricate role of CXCR4 in cancer. Adv. Cancer Res. 124: 31-82
Product options: 10
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GBP 175.00
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tests
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GBP 80.00
for 100
tests
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GBP 190.00
for 30
tests
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GBP 100.00
for 100
tests
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GBP 240.00
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tests
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GBP 70.00
for 100
tests
(1)
GBP 175.00

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