CD163 antibodies, human

CD163 antibodies, human

Clone: GHI/61.1 | Dilution: 1:11
The monoclonal antibody GHI/61.1 reacts with human CD163, a single-chain transmembrane protein also known as hemoglobin scavenger receptor or M130. It is expressed by mature tissue macrophages and peripheral blood monocytes. The expression of CD163 is up-regulated
in vitro
and
in vivo
by anti-inflammatory mediators such as IL-10 and (gluco)corticosteroid and is shed to blood upon inflammatory activation of macrophages. CD163 functions as a high affinity scavenger receptor for the complex of haemoglobin and haptoglobin. Depending on the ligand, crosslinking of M130 initiates signal transduction leading to the production of proinflammatory cytokines Il-1ß, IL-6, and GM-CSF or the antiinflammatory cytokine IL-10.

Alternative names

GHI/61, M130, MM130, CD163

Technical specifications

  • Antigen: CD163
  • Clone: GHI/61.1
  • Isotype: mouse IgG1κ
  • Isotype control: Mouse IgG1 – isotype control antibodies
  • Alternative names of antigen: GHI/61, M130, MM130, CD163
  • Entrez Gene ID: 9332
  • Molecular mass of antigen [kDa]: 121
  • Cross-reactivity:
    cynomolgus monkey (
    Macaca fascicularis
    )
  • Distribution of antigen: bone marrow, CNS cells, liver, macrophages, monocytes, spleen, thymocytes
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, APC, VioBlue, PE-Vio770, Biotin
  • Selected references

    1. Kristiansen, M. et al. (2001) Identification of the haemoglobin scavenger receptor. Nature 409(6817): 198-201
    2. Law, S. K. et al. (1993) A new macrophage differentiation antigen which is a member of the scavenger receptor superfamily. Eur. J. Immunol. 23(9): 2320-2325
    3. Ritter, M. et al. (2001) Interaction of CD163 with the regulatory subunit of casein kinase II (CKII) and dependence of CD163 signaling on CKII and protein kinase C. Eur. J. Immunol. 31(4): 999-1009
    4. Pulford, K. et al. (1992) A monocyte/macrophage antigen recognized by the four antibodies GHI/61, Ber-MAC3, Ki-M8 and SM4. Immunology 75(4): 588-595
    5. Burdo, T. H. et al. (2011) Soluble CD163 made by monocyte/macrophages is a novel marker of HIV activity in early and chronic infection prior to and after anti-retroviral therapy. J. Infect. Dis. 204: 154-163
Product options: 9
for 30
tests
(1)
GBP 60.00
for 100
tests
(1)
GBP 150.00
130-100-612

CD163-APC, human

for 30
tests
(1)
GBP 70.00
130-097-630

CD163-APC, human

for 100
tests
(1)
GBP 175.00
for 30
tests
(1)
GBP 75.00
for 100
tests
(1)
GBP 185.00
for 30
tests
(1)
GBP 80.00
for 100
tests
(1)
GBP 190.00
for 100
tests
(1)
GBP 150.00

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