CD161 antibodies, human

CD161 antibodies, human

Clone: REA631 | Dilution: 1:50
Clone REA631 recognizes the human CD161 antigen, a 80 kDa single-pass type II membrane protein, which is also known as natural killer cell surface protein P1A (NKR-P1A) or C-type lectin domain family 5 member B (CLEC5B). CD161 is expressed on most natural killer (NK) cells and subsets of T cells. In peripheral blood, CD161 is preferentially expressed on T cells of memory phenotype, but it can also be found on subsets of thymocytes and fetal liver T cells. CD161 has been implicated in triggering NK-mediated cytotoxicity, contributing to target cell recognition by NK cells.
Additional information: Clone REA631 displays negligible binding to Fc receptors.

Alternative names

NKR-P1A, HNKR-P1a, CLEC5B

Technical specifications

  • Antigen: CD161
  • Clone: REA631
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: NKR-P1A, HNKR-P1a, CLEC5B
  • Entrez Gene ID: 3820
  • Molecular mass of antigen [kDa]: 25
  • Distribution of antigen: liver, NK cells, T cells, thymocytes
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: VioBright FITC, PE, APC, PE-Vio770, Biotin, VioBright 515, PE-Vio615
  • Selected references

    1. Lanier, L. L. et al. (1994) Human NKR-P1A. A disulfide-linked homodimer of the C-type lectin superfamily expressed by a subset of NK and T lymphocytes. J. Immunol. 153: 2417-2428
    2. Pozo, D. et al. (2006) CD161 (human NKRP1A) signaling in NK cells involves the activation of acid sphingomyelinase. J. Immunol. 176: 2397-2406
    3. Takahashi, T. et al. (2006) Expression of CD161 (NKR-P1A) defines subsets of human CD4 and CD8 T cells with different functional activities.​ J. Immunol. 176: 211-216
Product options: 14
for 30
tests
(1)
GBP 80.00
for 100
tests
(1)
GBP 195.00
130-114-122

CD161-PE, human

for 30
tests
(1)
GBP 70.00
130-113-596

CD161-PE, human

for 100
tests
(1)
GBP 180.00
130-114-121

CD161-APC, human

for 30
tests
(1)
GBP 70.00
130-113-595

CD161-APC, human

for 100
tests
(1)
GBP 180.00
for 30
tests
(1)
GBP 80.00
for 100
tests
(1)
GBP 195.00
for 30
tests
(1)
GBP 60.00
for 100
tests
(1)
GBP 155.00
for 30
tests
(1)
GBP 105.00
for 100
tests
(1)
GBP 245.00
for 30
tests
(1)
GBP 80.00
for 100
tests
(1)
GBP 195.00

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