CD144 (VE-Cadherin) antibodies, human

CD144 (VE-Cadherin) antibodies, human

Clone: REA199 | Dilution: 1:11
Clone REA199 recognizes CD144 (VE-Cadherin), a 120 KDa type II cadherin. Cadherins are cell adhesion molecules and mediate Ca
2+
dependent homophilic interactions. CD144 contains five extracellular cadherin (EC) domains and like other cadherins can interact directly via its C-terminus with cytoplasmic proteins such as β-catenin, plaktoglobin, and p120. Plaktoglobin und β-catenin bind to α-catenin, which in turn interacts with several actin-binding proteins, α-actinin, ajuba, zonula occludens-1 (ZO-1). Further indirect interactions of CD144 with partners such as SHP-2, VEGFR-2, Csk, and PAR-3, 6 allows CD144 to not only regulate the stability and strength of cell adhesion but also to serve functions such as sensing of shear forces, anti-proliferative, and anti-apoptotic effects.
Additional information: Clone REA199 displays negligible binding to Fc receptors.

Alternative names

CDH5, 7B4

Technical specifications

  • Antigen: CD144 (VE-Cadherin)
  • Clone: REA199
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: CDH5, 7B4
  • Molecular mass of antigen [kDa]: 120
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, APC, VioBlue, PE-Vio770, PerCP-Vio700, Biotin
  • Selected references

    1. Vincent, P. A. et al. (2004) VE-cadherin: adhesion at arm's length. Am. J. Physiol., Cell Physiol. 286: C987-C997
    2. Nelson, C. M. and Chen, C. S. (2003) VE-cadherin simultaneously stimulates and inhibits cell proliferation by altering cytoskeletal structure and tension. J. Cell. Sci. 116: 3571-3581
    3. Odell, A. F. et al. (2012) A VE-cadherin–PAR3–α-catenin complex regulates the Golgi localization and activity of cytosolic phospholipase A2α in endothelial cells. Mol. Biol. Cell 23: 1783-1796
Product options: 11
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GBP 75.00
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GBP 185.00
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GBP 80.00
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GBP 190.00
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(1)
GBP 80.00
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tests
(1)
GBP 190.00
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GBP 60.00
for 100
tests
GBP 150.00