CD140a antibodies, mouse

CD140a antibodies, mouse

Clone: REA637 | Dilution: 1:50
Clone REA637 recognizes the mouse CD140a antigen, a single-pass type I membrane protein, also known as platelet-derived growth factor receptor alpha (PDGFRα). CD140a is a receptor tyrosine kinase that forms homodimers or heterodimers with CD140b (PDGFRβ). Receptor dimerization and transphosphorylation at tyrosine residues activates the intracellular kinase activity. CD140a is broadly expressed in embryonic tissue, mostly in cells of mesodermal origin in adult tissue, and embryonic stem cell–derived cardiomyogenic cells. Expression of CD140a is associated with various malignancies.
Additional information: Clone REA637 displays negligible binding to Fc receptors.

Alternative names

PDGF-R-alpha, PDGFR-alpha, PDGFR-α

Technical specifications

  • Antigen: CD140a
  • Clone: REA637
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: PDGF-R-alpha, PDGFR-alpha, PDGFR-α
  • Entrez Gene ID: 18595
  • Molecular mass of antigen [kDa]: 120
  • Distribution of antigen: bone marrow, epithelial cells, fibroblasts, mesenchymal stem cells, monocytes, myeloid cells, osteoblasts, red blood cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: APC, PE
  • Selected references

    1. Takakura, N. et al. (1997) PDGFRα expression during mouse embryogenesis: immunolocalization analyzed by whole-mount immunohistostaining using the monoclonal antibody anti-mouse PDGFR alpha antibody APA5. J. Histochem. Cytochem. 45(6): 883-893
    2. Ntokou, A. et al. (2015) Characterization of the platelet-derived growth factor receptor α-positive cell lineage during murine late lung development. Am. J. Physiol. Lung Cell Mol. Physiol. 309(9): L942-948
    3. Zhou, Q. et al. (2015) Cardiac telocytes are double positive for CD34/PDGFR‑α. J. Cell. Mol. Med. 19(8): 2036-2042
Product options: 2

CD140a-PE, mouse

30 µg in 200 µL (1)
GBP 50.00
30 µg in 200 µL (1)
GBP 50.00

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