Anti-TSPAN8 antibodies, human

Anti-TSPAN8 antibodies, human

Clone: REA443 | Dilution: 1:50
Clone REA443 recognizes the human tetraspanin-8 (TSPAN8) antigen, a multi-pass membrane protein which is also known as transmembrane 4 superfamily member 3 (TM4SF3) or tumor-associated antigen CO-029. TSPAN8 is a member of the transmembrane 4 superfamily, which is a group of cell surface glycoproteins that contain four transmembrane domains and two conserved extracellular loops. Tetraspanins interact and form complexes with a wide variety of proteins, including other members of the tetraspanin family, integrins, receptors, and signaling molecules. Through these interactions, they play important roles in fundamental cellular processes such as migration, proliferation, and differentiation. It is suggested that TSPAN8 is widely expressed in various tissues, including in the digestive tract, connective tissue, bone, muscle, and kidney. TSPAN8 has also been intensively studied in the field of cancer. It has been shown to be highly expressed in colorectal, hepatocellular, and pancreatic carcinoma cells along with integrin family proteins. Several studies have suggested that TSPAN8 is also involved in the migration and invasion of cancer cells.
Additional information: Clone REA443 displays negligible binding to Fc receptors.

Alternative names

CO-029, TM4SF3, Tspan-8, D6.1A

Technical specifications

  • Antigen: TSPAN8
  • Clone: REA443
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: CO-029, TM4SF3, Tspan-8, D6.1A
  • Entrez Gene ID: 7103
  • Molecular mass of antigen [kDa]: 26
  • Distribution of antigen: muscle, bone, kidney, colorectal carcinoma cells, hepatocellular carcinoma cells, pancreatic carcinoma cells, other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE
  • Selected references

    1. Szala, S. et al. (1990) Molecular cloning of cDNA for the human tumor-associated antigen CO-029 and identification of related transmembrane antigens. Proc. Natl. Acad. Sci. U.S.A. 87(17): 6833-6837
    2. Nazarenko, I. et al. (2010) Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation. Cancer Res. 70(4): 1668-1678
    3. Hirukawa, T. et al. (2014) Kidney diseases enhance expression of tetraspanin-8: a possible protective effect against tubular injury. Nephron Extra 4(1): 70-81
Product options: 2
for 30
GBP 70.00
for 100
GBP 180.00

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