Anti-TIGIT antibodies, human

Anti-TIGIT antibodies, human

Clone: 4E1.2 | Dilution: 1:11
Clone 4E1.2 reacts with a protein containing an immunoglobulin variable (IgV) domain, a transmembrane domain, and an immunoreceptor tyrosine-based inhibitory motif (ITIM), which is called TIGIT (T cell immunoglobulin and ITIM domain). It is expressed on T cells, including Treg cells and memory subsets, as well as on NK cells. The poliovirus receptor (PVR; also called NECL5 or CD155) is a high-affinity coreceptor for TIGIT that is highly expressed on dendritic cells (DCs), fibroblasts, endothelial cells, and some tumor cells. The interaction of TIGIT with PVR on DCs leads to the down-regulation of pro-inflammatory cytokine secretion and the induction of IL-10 production in DCs, exerting an inhibitory effect on T cell activation.

Alternative names


Technical specifications

  • Antigen: TIGIT
  • Clone: 4E1.2
  • Isotype: mouse IgG3κ
  • Alternative names of antigen: VSIG9, Vstm3, WUCAM
  • Entrez Gene ID: 201633
  • Molecular mass of antigen [kDa]: 24
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: Biotin
  • Selected references

    1. Yu, X. et al. (2008) The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells. Nat. Immunol. 10: 48-57
Product options: 1
for 100
GBP 155.00