Anti-TCR Vβ1 antibodies, human

Anti-TCR Vβ1 antibodies, human

Clone: REA662 | Dilution: 1:50
Clone REA662 recognizes the human variable beta 1 subunit of the αβ T cell receptor (TCR Vβ1). The TCR is a heterodimeric glycoprotein associated with the CD3 antigen. The α and β TCR chains are composed of constant and variable regions, each encoded by distinct gene segments. TCR Vβ1 is a variant of the TCR β chain. αβ T cells express a diverse αβ TCR repertoire that specifically co-recognizes self or foreign antigen bound to antigen-presenting molecules, which thereby leads to T cell–mediated immunity. For example, the TCR can directly bind to peptide fragments, riboflavin precursors, and lipid antigens that are presented by major histocompatibility complex (MHC) molecules, MR1 and CD1, respectively. In each case, the antigen sits within the antigen-binding cleft, whereupon the TCR recognizes a composite surface formed by the antigen-presenting molecule and surface-exposed regions of the antigen itself. This co-recognition paradigm is a central tenet of αβ T cell–mediated immunity and underpins MHC restriction.
Additional information: Clone REA662 displays negligible binding to Fc receptors.

Technical specifications

  • Antigen: TCR Vβ1
  • Clone: REA662
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Entrez Gene ID: 28621, 6957
  • Distribution of antigen: T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC
  • Selected references

    1. Born, W. et al. (1985) Rearrangement of T-cell receptor beta-chain genes during T-cell development. Proc. Natl. Acad. Sci. U.S.A. 82(9): 2925-2929
    2. Dunon, D. et al. (1994) T cell migration during development: homing is not related to TCR V beta 1 repertoire selection. EMBO J. 13(4): 808-815
    3. van den Beemd, R. et al. (2000) Flow cytometric analysis of the Vbeta repertoire in healthy controls. Cytometry 40(4): 336-345
    4. Wei, S. et al. (1994) The extent of the human germline T-cell receptor V beta gene segment repertoire. Immunogenetics 40(1): 27-36
Product options: 2
for 30
tests
(1)
GBP 60.00
for 100
tests
(1)
GBP 150.00

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