Anti-Sox2 antibodies, human and mouse

Clone: REA320 | Dilution: 1:11
Clone REA320 recognizes the human and mouse Sox2 antigen, a member of the SRY-related HMG-box family of transcription factors. The SRY-containing protein Sox2 is known to regulate the self-renewal of mouse and human embryonic stem cells. It is also important for the maintenance of stem cells in multiple adult tissues including brain and trachea, and it is one of the key transcription factors for establishing induced pluripotent stem cells. Sox2 forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1, and ZFP206. Overexpression and gene amplification of Sox2 have been associated with the development of squamous cell carcinoma in multiple tissues such as the lung and esophagus.
Additional information: Clone REA320 displays negligible binding to Fc receptors.

Alternative names

ANOP3, MCOPS3, lcc, ysb

Technical specifications

  • Antigen: Sox2
  • Clone: REA320
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: ANOP3, MCOPS3, lcc, ysb
  • Entrez Gene ID: 6657
  • Molecular mass of antigen [kDa]: 34
  • Distribution of antigen: brain, lung
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, APC, pure
  • Selected references

    1. Liu, K. et al. (2013) The multiple roles for Sox2 in stem cell maintenance and tumorigenesis. Cell. Signal. 25(5): 1264-1271
    2. Fantes, J. et al. (2003) Mutations in SOX2 cause anophthalmia. Nat. Genet. 33(4): 461-463
    3. Maucksch, C. et al. (2013) Concise review: the involvement of SOX2 in direct reprogramming of induced neural stem/precursor cells. Stem Cells Transl Med 2(8): 579-583
Product options: 5
for 30
GBP 60.00
for 100
GBP 155.00
for 30
GBP 70.00
for 100
GBP 180.00
100 µg in 1 mL
GBP 110.00

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