Anti-Plexin-B2 antibodies, human

Anti-Plexin-B2 antibodies, human

Clone: REA626 | Dilution: 1:11
Clone REA626 recognizes the human plexin-B2 antigen, a single-pass type I membrane protein, which belongs to the semaphorin receptor family, B subfamily. Plexin-B2 is expressed in the nervous system and on other cells including cells of the immune system. It is expressed on T cells and T cell–dependent germinal center B cells. Expression is also found on macrophages, conventional dendritic cells, and plasmacytoid dendritic cells. Plexin-B2 plays an important role in cell-cell signaling, axon guidance, invasive growth, and cell migration. It has several semaphorin ligands including semaphorin-3E, semaphorin-4A, semaphorin-4C, and semaphorin-4D (CD100). Binding to class 4 semaphorins promotes the downstream activation of RHOA and phosphorylation of ERBB2. During skin damage repairs, CD100 interacts with plexin-B2 on γδ T cells to play a role in the healing process.
Additional information: Clone REA626 displays negligible binding to Fc receptors.

Alternative names

Plxnb2, MM1, Nbla00445, dJ402G11.3

Technical specifications

  • Antigen: Plexin-B2
  • Clone: REA626
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: Plxnb2, MM1, Nbla00445, dJ402G11.3
  • Entrez Gene ID: 23654
  • Molecular mass of antigen [kDa]: 203
  • Distribution of antigen: dendritic cells, macrophages, T cells, astrocytes, microglia, neurons, oligodendrocytes, other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio770
  • Selected references

    1. Deng, S. et al. (2007)
      Plexin-B2, but not Plexin-B1, critically modulates neuronal migration and patterning of the developing nervous system
      in vivo
      .
      J. Neurosci. 27(23): 6333-6347
    2. Witherden, D.A. et al. (2012) The CD100 receptor interacts with its plexin B2 ligand to regulate epidermal γδ T cell function. Immunity 37(2): 314-325
    3. Le, A. P. et al. (2015) Plexin-B2 promotes invasive growth of malignant glioma. Oncotarget 6(9): 7293-7304
Product options: 6
for 30
tests
(1)
GBP 75.00
for 100
tests
(1)
GBP 180.00
for 30
tests
(1)
GBP 75.00
for 100
tests
(1)
GBP 180.00
for 30
tests
(1)
GBP 80.00
for 100
tests
(1)
GBP 190.00

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