Anti-Ly-49C/F/I/H antibodies, mouse

Anti-Ly-49C/F/I/H antibodies, mouse

Clone: 14B11 | Dilution: 1:50
Clone 14B11 recognizes a common epitope of the mouse Ly-49C/F/I/H family members which are single-pass type II C-type lectin-like membrane glycoproteins, also known as Ly-49 inhibitory receptors C, F, and I and activating receptor H. It does not react with other Ly-49 members. The Ly-49 receptors are encoded by a family of highly polymorphic and polygenic genes within the mouse NK gene complex which includes genes that encode both inhibitory and activating Ly-49 receptors. Ly-49 receptors recognize MHC-I and MHC-I-like proteins on normal as well as altered cells. They are described as being expressed on both the developing and mature NK cells. The inhibitory Ly-49 receptors are involved in NK cell education, a process in which NK cells acquire function and tolerance toward cells that express “self-MHC-I.” On the other hand, the activating Ly-49 receptors recognize altered cells expressing activating ligands. Ly-49 receptors have been described on multiple NK cell subsets, such as uterine NK and memory NK cells, as well as NKT cells, dendritic cells, plasmacytoid dendritic cells, macrophages, neutrophils, and cells of the adaptive immune system, such as activated T cells and regulatory CD8
T cells.

Alternative names

Klra3, Klra6, Klra8, Klra9

Technical specifications

  • Antigen: Ly-49C/F/I/H
  • Clone: 14B11
  • Isotype: hamster IgG
  • Alternative names of antigen: Klra3, Klra6, Klra8, Klra9
  • Entrez Gene ID: 16634, 16637, 16640, 16639
  • Molecular mass of antigen [kDa]: 31
  • Distribution of antigen: NK cells, NKT cells, dendritic cells, macrophages, neutrophils, T cells, other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: APC-Vio770
  • Selected references

    1. Wong, S. et al. (1991) Ly-49 multigene family. New members of a superfamily of type II membrane proteins with lectin-like domains. J. Immunol. 147(4): 1417-1423
    2. Tu, M. M. et al. (2014) Ly49 family receptors are required for cancer immunosurveillance mediated by natural killer cells. Cancer Res. 74(14): 3684-3694
    3. Rahim, M. M. et al. (2014) Ly49 receptors: innate and adaptive immune paradigms. Front Immunol 5: 145-145
Product options: 1
30 µg in 200 µL (1)
GBP 70.00

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