Anti-IL-17A antibodies, mouse

Anti-IL-17A antibodies, mouse

Clone: REA660 | Dilution: 1:50
Clone REA660 recognizes mouse interleukin 17A (IL-17A). Interleukin 17 (IL-17) is a family of cytokines that play a central role in adaptive immunity as well as autoinflammatory disorders. Data from several mouse models suggest that IL-17 plays a key role in the host defense against certain extracellular bacterial infections.
Recently, a new mouse T helper cell subset has been identified, which is dinstinct from Tʜ1 and Tʜ2 cells: IL-17–producing CD4
T helper (Tʜ17) cells. Tʜ17 cells preferentially produce IL-17A, IL-17F, IL-21, and IL-22. Receptors for IL-17 and IL-22 are expressed on various epithelial tissues, thus Tʜ17 cells are crucial for the cross-talk between immune system and tissues. It is now established that Tʜ17 cells are responsible for driving autoimmune inflammation. After stimulation of mouse T cells, IL-17 is not only secreted by CD4
T cells, but also by CD8
T cells and γδ T cells.
Additional information: Clone REA660 displays negligible binding to Fc receptors.

Alternative names

CTLA-8, IL-17

Technical specifications

  • Antigen: IL-17A
  • Clone: REA660
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: CTLA-8, IL-17
  • Entrez Gene ID: 16171
  • Molecular mass of antigen [kDa]: 15
  • Distribution of antigen: epithelial cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC
  • Selected references

    1. Zheng, S. et al. (2017) Human gingiva-derived mesenchymal stem cells ameliorate Streptozoticin-induced T1DM in mice via suppression of T effector cells and up-regulating Treg subsets. Sci. Rep. 7(1): 15249
    2. Kennedy, J. et al. (1996)
      Mouse IL-17: a cytokine preferentially expressed by alpha beta TCR + CD4
      T cells.
      J. Interferon Cytokine Res. 16(8): 611-617
    3. Weaver, C. T. et al. (2007) IL-17 family cytokines and the expanding diversity of effector T cell lineages. Annu. Rev. Immunol. 25: 821-852
    4. Ouyang, W. et al. (2008) The biological functions of T helper 17 cell effector cytokines in inflammation. Immunity 28: 454-467
Product options: 6
30 µg in 200 µL (1)
GBP 30.00
150 µg in 1 mL (1)
GBP 80.00
30 µg in 200 µL (1)
GBP 50.00
150 µg in 1 mL (1)
GBP 155.00
30 µg in 200 µL (1)
GBP 50.00
150 µg in 1 mL (1)
GBP 155.00

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