Anti-GATA3 antibodies, human and mouse

Anti-GATA3 antibodies, human and mouse

Clone: REA174 | Dilution: 1:50
Clone REA174 recognizes GATA3, a member of the GATA family of transcription factors. Like other members of the family, GATA3 contain zinc finger motifs involved in recognizing the canonical GATA DNA sequence. GATA3 has two trans-activating domains and two zinc finger domains, each followed by a conserved basic region. Expression of GATA3 is found in developing and mature T cells, natural killer (NK) cells, subset of NKT cells, and endothelial cells. Primary function attributed to GATA3 is to regulate the T helper 2 (Tʜ2) cell differentiation. However, role of GATA3 is also recognized in early T cell commitment and CD4
+
T cell development .
Additional information: Clone REA174 displays negligible binding to Fc receptors.      

Alternative names

HDR, HDRS, jal

Technical specifications

  • Antigen: GATA3
  • Clone: REA174
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: HDR, HDRS, jal
  • Entrez Gene ID: 2625
  • Molecular mass of antigen [kDa]: 48
  • Distribution of antigen: T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC
  • Selected references

    1. Ho, I. et al. (2007) GATA-3 - not just for Tʜ2 cells anymore. Cell. Mol. Immunol. 4(1): 15-29
    2. Zaiss, D. M. et al. (2017) Epidermal growth factor receptor expression licenses type-2 helper T cells to function in a T cell receptor-independent fashion. Immunity 47(4): 710-722
    3. Ting, C. N. et al. (1996) Transcription factor GATA-3 is required for development of the T-cell lineage. Nature 284(6608): 474-478
    4. Joulin, V. et al. (1991) A T-cell specific TCR delta DNA binding protein is a member of the human GATA family. EMBO J. 10: 1809-1816
    5. Martinelli, G. et al. (2018) Immunosuppressive Treg cells acquire the phenotype of effector-T cells in chronic lymphocytic leukemia patients. J. Transl. Med. 16(1): 172
    6. Qian, L. et al. (2014) Alkylglycerols modulate the proliferation and differentiation of non-specific agonist and specific antigen-stimulated splenic lymphocytes. PLoS One 9(4): e96207
Product options: 2
for 30
tests
(1)
GBP 60.00
for 100
tests
(1)
GBP 150.00

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