Anti-EphA2 antibodies, mouse

Anti-EphA2 antibodies, mouse

Clone: REA579 | Dilution: 1:10
Clone REA579 recognizes the mouse EphA2 antigen, which is a member of the receptor tyrosine kinases that are activated in response to binding ephrin. The ephrin receptor (Eph) family of receptor tyrosine kinases is the largest family of receptor tyrosine kinases.
Ephs are divided into two subclasses, EphAs and EphBs, based on sequence similarity and on their binding affinity to ephrin-A ligands or the transmembrane-bound ephrin-B ligands.
Eph receptors and ephrins regulate the adhesion of endothelial cells and are required for the remodeling of blood vessels and may be involved in cell-cell interactions guiding early hindbrain development. It is up-regulated on many aggressive carcinoma cells including aggressive ovarian, cervical and breast carcinomas, and lung cancer.
Additional information: Clone REA579 displays negligible binding to Fc receptors.

Alternative names

Eck, Myk2, Sek2

Technical specifications

  • Antigen: EphA2
  • Clone: REA579
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: Eck, Myk2, Sek2
  • Entrez Gene ID: 13836
  • Molecular mass of antigen [kDa]: 106
  • Distribution of antigen: endothelial cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, Biotin
  • Selected references

    1. Gilardi-Hebenstreit, P. et al. (1992) An Eph-related receptor protein tyrosine kinase gene segmentally expressed in the developing mouse hindbrain. Oncogene 7(12): 2499-2506
    2. Ruiz, J.C. and Robertson, E.J. (1994) The expression of the receptor-protein tyrosine kinase gene, eck, is highly restricted during early mouse development. Mech. Dev. 46(2): 87-100
    3. No authors listed (1997) Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee. Cell 90(3): 403-404
Product options: 6
9 µg in 300 µL (1)
GBP 20.00
30 µg in 1 mL (1)
GBP 50.00
9 µg in 300 µL (1)
GBP 30.00
30 µg in 1 mL (1)
GBP 50.00
9 µg in 300 µL (1)
GBP 10.00
30 µg in 1 mL (1)
GBP 30.00

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